Building Blocks
Unusual Building Blocks Peptide Synthesis, Peptidomimetic and Medicinal Chemistry
Spermines, Spemidines and other Biogenic Polyamines Interact with DNA! Polyamines stabilise nucleic acids against chemical and enzymatic degradation, facilitate the formation of secondary and tertiary structures and enhance cellular uptake.
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Andrew J. Marsh, David M. Williams and Jane A. Grasby; Organic & Biomolecular Chemistry, 2004; 2: 2103 – 2112 |
| SNN1070 | Spermine(HFFB) * HCl N4-(t-Butyloxycarbonyl)-N2,N3-bis-(9-fluorenylmethyloxycarbonyl)-1,5,10,14-tetra-aza-quatrodecan hydrochloride C45H54N4O6*HCl, 746,96*36,45 g/mole |
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Spermine participates in oxidative damage of guanosine and 8-oxoguanosine leading to deoxyribosylurea formation.
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Hosford ME, Muller JG, Burrows CJ; J. Am. Chem. Soc. 2004; 126: 9540-9541 |
Structural Analysis of DNA Interactions with Biogenic Polyamines and Cobalt(III)hexamine Studied by Fourier Transform Infrared and Capillary Electrophoresis; Biogenic polyamines, such as putrescine and spermidine are involved in numerous diverse biological processes. Due to their binding to DNA and RNA they play an important role in nucleic acid function and cause DNA condensation and aggregation inducing DNA conformational changes.
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Amin Ahmed Ouameur and Heidar-Ali Tajmir-Riahi; J. Biol. Chem. 2004; 279(40): 42041-42054. |
Small molecules bind to DNA quadruplexes [d(G3T4G3)]2 and spermine has a stronger affinity for folded DNA quadru-plexes over duplex DNA and linear quadruplexes. Keniry, M. A. Quadruplex structures in nucleic acids.
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Biopolymers 2001; 56: 123-146. |
N-Benzyl-Amino Acids – A Smart Chiral Pool for High Diversity Chemistry
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References: Synthesis of protected amino alcohols and aldehydes: Synthesis of N-Allyl amino acids and amino alcohol: Synthesis of unnatural amino acids: Synthesis of asymmetric polyamines: Synthesis open chain chiral compounds: Synthesis of α-hydrazino amino acids: |
Allylglycine - A highly versatile Building Block for the Synthesis of Heterocycles and for Peptidomimetic
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References: Allylglycine, Homoallylglycine Pipecolic Acid Derivatives Addition to the Double Bond Prolines Heterocycles Oxidations Epoxides |
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Dates & Exhibitions
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June 22nd– 27th, 2013
Hilton Waikoloa Village
Hawai‘i, USA
The Symposium will follow its long standing tradition of featuring talks by leading scientists from the academic and industry communities sharing current and compelling peptide research.