Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors.

May 26th - 31st, 2013
Le Lazaret
Sète, France

Iris Biotech GmbH will be present during the talks and supports the organisation with a booth at the exhibition. We are pleased to get in personal contact with you.

June 10th-12th, 2013
Auditorio AXA
Barcelona, Spain

Barcelona meeting will be fifth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009) and Budapest (2011) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge from chemistry to biology. 

June 18th-19th, 2013
Newmarket Racecourse Conference Centre,
Cambridge, UK

This 2-day conference and exhibition will feature top-level papers from industry and academia enabling delegates to learn how they can improve their research and development in the areas of peptide discovery, development, manufacture and application.

June 22nd– 27th, 2013
Hilton Waikoloa Village
Hawai‘i, USA

The Symposium will follow its long standing tradition of featuring talks by leading scientists from the academic and industry communities sharing current and compelling peptide research.

DTNB, frequently called Ellman’s Reagent, used as reagent for determination of free sulfhydryl groups. Through reaction with aliphatic thiol groups a mixed disulfide of protein thiol and one mole of 2-nitro-5-thiobenzoate per mole of protein sulfhydryl group is being formed. DTNB has little absorbance. Reaction with -SH groups on proteins (from any solvent accessible Cys) under mild alkaline conditions (pH 7-8) produces the 2-nitro-5-thiobenzoate anion, which gives an intense yellow color with an absorption maximum at 409.5 nm (Extinction coefficient: 14150 M ^-1*cm ^-1). Ellman’s reagent is sensitive to various buffer ions, therefore, the extinction coefficient used to calculate the number of sulfhydryl groups must be matched to the reaction conditions. In case the thiol groups are in disulfide bonds, they must be reduced under anaerobic conditions prior to reaction with DTNB. 
Solubility 8 mg/mL in EtOH. Stock solutions c an be prepared in 0.1 M phosphate buffer, which are stable over several weeks.

April 22-25, 2013
McCormick Place, Chicago, Illinois

Iris Biotech GmbH will participate at the international Bio Convention 2013 in Chicago, USA. We would be glad to meet you.

April 24th, 2013
Netherlands Cancer Institute
Amsterdam, Netherlands

In 2013 the NKI-AVL (Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital) will celebrate its 100^th anniversary and in the same year the NKI peptide facility will be operational for 25 years.

March 18th-21st, 2013
TU Munich
Munich, Germany

The meeting will cover many fields of peptide science including peptides/peptidomimetics in medicine, peptide and protein synthesis, peptide structure and folding, peptide interactions, and peptide misfolding and self-assembly.

Long-chain acylcarnitines are well-known intermediates in mitochondrial fatty acid oxidation

March 13-14th 2013
At the Technical University Munich, Germany

The azido function can be used for different applications

January 22nd - 23rd, 2012
DECHEMA-Haus
Frankfurt am Main, Germany

The organizing committee cordially invites you to the 8th Status Seminar on Chemical Biology which will present cutting-edge research at the prolific interface of chemistry and biology.

A prominent luciferase group was first discovered in Coelenterata and the corresponding light emitting molecule was therefore named coelenterazine.

Building Blocks for the synthesis of 2,3-diaminobutanoic acid containing peptides or for Click reactions.

Fmoc-Sieber amide resin is an acid-labile carrier for solid phase synthesis of peptide amides. Cleavage can be achieved with only 1% TFA in DCM making them an ideal carrier for the synthesis of protected peptide fragments in fragment condensation strategies for the synthesis of long peptides. It has also been used in organic synthesis of acid-sensitive compounds, for targeted synthesis of primary amines and N-alkylated secondary carboxyamides.

October 10th-12th, 2012
Yokohama, Japan

Meet our CEO and Mrs. Annick Vancolen and discuss the latest trends and ideas at our booth. Additional we will take part in the partnering and are looking forward to meet you.

October 9th-11th, 2012
Feria de Madrid, Spain

CPhI Worldwide 2012 is the best place to network with the global pharmaceutical community, source new suppliers, build relationships with existing partners and identify new business opportunities.

Biotin-PEG Reagent for efficient and smooth capturing and purification of antibody-antigen-complexes.

For antibody labeling via NHS chemistry. Capturing the antibody-antigen complex with streptavidin and isolating of the target protein. Elution of the immune complex from the streptavidin using DTT. Otherwise strong denaturating conditions typically required to break the streptavidin-biotin interaction have to be applied. For very high sensitivity.

September 2nd - 7th, 2012
Athens, Greece
Megaron Conference Centre

With more than 550 submitted abstracts and more than 500 already registered participants coming from more than 40 different countries, the 32nd European Peptide Symposium assures an exciting scientific program.

Proline derivatives with azido function at position 4 enable Click conjugation just at the edge of a beta-turn. Both optical configurations, 4S and 4R, are available, in order to direct the conjugate specifically in the direction of desire.

Press release (german text, pdf Download-Version)

IRIS Biotech bringt neue Innovationen auf den Markt

Das in Marktredwitz in Oberfranken/Ostbayern beheimatete Unternehmen IRIS Biotech GmbH hat durch Intensivierung seiner Zusammenarbeit mit Forschungsinstitutionen den Zeitraum der Markteinführung neuer Produktgruppen drastisch verkürzt. Derzeit kooperiert das Unternehmen mit 35 ausgewählten Herstellern und Universitäten aus aller Welt...

July 15th - 20th, 2012
Leuven, Belgium

The BOSS-conference is a unique international symposium as it combines lectures delivered by established organic chemists as well as younger rising stars with two prestigious events: a lecture delivered by the recipient of the “Janssen Pharmaceutica Prize for Creativity in Organic Synthesis”, and the “Tetrahedron Chair”: a one-day course on a specific topic in organic synthesis.

Prof. Erick M. Carreira (ETH Zürich) has accepted to be chairman of BOSS XIII which will take place in Leuven (Belgium), from July 15 to 20, and hosted by Prof. Erik Van der Eycken (KU Leuven).

July 04th-06th, 2012
Poitiers, France

This major international symposium will gather more than 450 scientists from around the world at the Faculty of Medicine and Pharmacy in Poitiers.

The scientific programme, which will include over 25 plenary lectures by internationally well-known scientists, focuses on "Interfacing Chemical Biology and Drug Discovery", covering the main stages of modern drug discovery.

June 07th-10th, 2012
Naples, Italy

The Workshop, designed to provide updated information and to critically discuss current trends on synthetic and conformational aspects of bioactive peptides, will deal in the 13th edition with the general topic: “Conformation and Activity in Peptides: Relationships and Interactions”.

June 18th-21st, 2012
Boston, USA

Iris Biotech GmbH will participate at the international Bio Convention 2012 in Boston, USA. We would be glad to meet you at our booth number 0828.

Condensation reagent especially suited for coupling of sterically hindered amino acids. Superior suppression of racemization.

May 28th-30th, 2012
Valencia, Spain

From Laboratory to Clinical Practice

For details on the meeting please follow this link to the official website of CIPF

May 20th–23rd, 2012
Las Vegas, NV, USA

For details on the meeting please follow this link to the official website of TIDES 2012

May 23rd, 2012
Zentrum für Umwelt und Kultur, Benediktbeuern, Germany

For details on the meeting please follow this link to the official website of Biopharmaceuticals Bayern

April 17th - 18th, 2012
Cambridge, UK

The Peptide Conference will take place in conjunction with our new Dynamic Outsourcing for Life Sciences (DOLS) event, which will add extra value to your participation.

April 2-3rd, 2012
CRDP - Montpellier, France

An International Symposium dedicated to Prolines and derivatives organized under the auspices of the GFPP

Iris Biotech GmbH will be present during the talks and supports the organisation with a booth at the Industrial Exhibition. We are pleased to get in personal contact with you.

Activation AND Protection SIMULTANEOUSLY
A smart technology for avoiding over-alkylation of primary amines

March, 29th - 31th, 2012
Mosbach, Germany

Once again outstanding scientists will present their work focussed on Posttranslational Modifications at the Mosbacher Kolloquium.

Under the headline "Post-translational modifications in signal integration and molecular Therapies" the Kollogium will be an interesting event.

March, 18th - 22th, 2012
Aussois, France

Depuis 1986, les RECOB (REncontres en Chimie Organique Biologique) réunissent tous les deux ans des chimistes, des physicochimistes, des biochimistes et des biologistes intéressés par l´interface chimie-biologie.

Les 14èmes REncontres en Chimie Organique Biologique (recob14) du 18 au 22 Mars 2012

Guanidino groups play an important role in proteolytic digestion of proteins, as they are essential as initial contact between active pockets of for example trypsin and substrates.

Spermines and other Biogenic Polyamines
interact due to their multi cationic structure with DNA!

February 12^th - 15^th, 2012
Dubai, UAE

This unique international conference provides a platform for all pharmaceutical scientists, internists and primary care physicians to discuss and learn about all the important international breakthrough developments in drug discovery and on new therapeutics.

February 9th - 10th, 2012
Brussels, Belgium

Since many years, the Belgian academic and industrial groups that are active in various aspects of peptide research did not have an opportunity to get to know each other and to discuss common interests.

Our portfolio currently contains over 5500 products. Many of them – in particular standard consumables for peptide synthesis – are being produced in bulk quantities.  Therefore we can keep our prices also for lab quantities at very competitive level.

7th Status Seminar on Chemical Biology

05th & 06th December 2011, at DECHEMA e.V. Theodor-Heuss-Allee 25, Germany

(events.dechema.de/chembio11)

5. Kooperationsforum "Drug Development – Strategien, Technologien, Therapien"

1st December 2011
Rudolf-Virchow-Zentrum der Universität Würzburg (www.bayern-innovativ.de/drugdevelopment2011)

Munich Biomarker Conference

Local Heroes and Global Challenges

29th November 2011 Hilton Munich City Hotel, Rosenheimer Str. 15,
81667 Munich, Germany (www.m4.de/)

• Readily applicable to biolabelling, Click 
  conjugation protocols and peptide synthesis
• Stable under buffer conditions (pH 4-8) 
  and in solid phase peptide synthesis
• Broadly applied in cell und animal 
  imaging, tested in FRET systems
• Available in larger quantities compared 
  to e.g. Alexa, Cy-Dyes etc.
• Purities > 85%, supplied as freeze-dried solid powder

Strategien – Technologien – Therapien

1. Dezember 2011,
Rudolf-Virchow-Zentrum, Würzburg

PGA (Penicillin G Amidase, Penicillin Acylase, Penicillin Amidohydrolase from E.coli on acrylic resin, Systematic name: Penicillin amidohydrolase, E.C. 3.5.1.11) has an active pocket, which is very specific for phenyl acetic acid. The prominent commercial use is hydrolysis of a phenylacetamid bond during production of the penicillin API 6-APA (De Martin et al., J. Mol. Catal. B:Enzymatic 1999; 6: 437). The high specifity of PGA towards the Phenylacetyl moiety makes the use of Phacm as new alternative for Acm very promising. The principle use already was discovered by Albericio et al in 1995 using native PGA. Today PGA is available as immobilized preparation, so by simple filtration process PGA can be removed from the reaction mixture and reused many times.

Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block.

The size can be designed from 250 g/mole for 1st generation dendrons to over 4400 g/mole with 5th generation compounds. Dendrimers can be designed reaching even a molecular weight of some 10.000 Da. As focal point alkyne and azido functions are used with appropriate counter parts in any type of click chemistry reaction. Olefinic functions offer the possibility for addition reaction or conjugation by metathesis reactions or photo reactions with the aid of UV light. For the modification of Gold surfaces sulphur bearing dendrons can be used, they also conjugate with biologicals via disulfide bridge formation.

Biotrans 2011

October 2 - 6, 2011 ITALY - ATAHOTEL NAXOS BEACH RESORT,
Giardini Naxos (Messina) Sicily (http://www.biotrans2011.org/)

alpha-Sulfo-beta-Alanine has been used to couple to hydrophobic labels like Cyanine and Rhodamine dyes and other hydrophobic residues to increase their solubility in water. As di- or tripeptide a further increase of hydrophilicity can be achieved. Fmoc-beta-Ala(SO3H)-OH can be coupled in SPPS by standard phosphonium or uronium based coupling reagents. In high throughput technologies for DNA sequencing and genomics charge-modified dye-labeled dideoxynucleoside-5’-triphosphates were synthesized for ‘direct-load’ applications in DNA sequencing.

9th Australian Peptide ConferencePeptides - by discovery and design

16th - 20th October 2011Hamilton Island, Queensland, Australia (http://peptides.asnevents.com.au/)

3rd Modern Solid Phase Peptide Synthesis & Its Applications Symposium

Daydream Island Resort, The Whitsundays, Queensland, Australia, 13-16 October 2011(www.spps2011.org)

Phacm shows the same stability and orthogonality as Acm and has the additional advantage that it can be deprotected simply by water in the presence of PGA. The addition of co-solvents like acetonitrile helps to improve the solubility of hydrophobic sequences. Water in combination with DMSO (80:20) will make deprotection and cyclization a one pot reaction, which is completed (37°C, pH 7) normally within 16h to 24h.

RICT 2011 - International Conference on Medicinal Chemistry

Lyon, France,
July 6th - 8th, 2011 (www.rict2011.org)

Lipase B from Candida antarctica (EC 3.1.1.3)
adsorbed on hydrophobic polymer Polystyrene DVB cross linked, 300-700µm,
Synthetic Activity >10.000 U/g (dry), 
very high mechanical stability - suitable for packed bed reactors

22nd American Peptide Symposium

San Diego, California, USA, UAE, Booth # 49
June 25th - 30th, 2011 (www.aps2011.org)

Reported applications:

Introduction of 9-fluorenylmethyloxycarbonyl, trichloroethoxycarbonyl, and benzyloxycarbonyl amine protecting groups into O-unprotected hydroxylamino acids using succinimidyl carbonates; Anelka Paquet; Can. J. Chem.; 1982; 60: 976.

Widely Applicable Deprotection Method of 2,2,2-Trichloroethoxycarbonyl (Troc) Group Using Tetrabutylammonium Fluoride; Cheng-yuan Huanga; Ning Wanga; Katsumasa Fujikia; Yuji Otsukaa; Masao Akamatsua; Yukari Fujimotoa; Koichi Fukasea; Journal of Carbohydrate Chemistry 2010; 29(6): 289 – 298.

BIO
The Global Event of Biotechnology 2011

Walter E. Washington Convention Center booth 2426 - Hall A - Germany Pavilion, Washington D.C.
June 27th - 30th, 2011 (convention.bio.org)

Cleland's reagent, also known as dithiothreitol or DTT is a water soluble protective reagent for sulfhydryl groups.
It reduces disulfide linkages to free sulfhydryl groups in proteins and enzymes.
It is a component of buffers used in protocols for the isolation and purification of proteins.

BAP XII
Biologically Active Peptides XII

Prague, Czech Republic
April 27th - 29th, 2011 (www.uochb.cas.cz/BAPXII)

MAOPS2
2nd International Microwave-Assisted Organic and Peptide Synthesis Symposium

Chiostro del Maglio, Firenze, Italy
April 27th - 29th, 2011 (maops.ibmm.cnrs.fr/)

The Peptide Conference 2011

Cambridge, UK
April 19-20, 2011 (www.avakado.eu/Peptide_Conference)

62nd Mosbacher Kolloquium "Mechanisms of RNA-mediated regulation"

Mosbach, Germany, 7. April -  9. April, 2011 (http://www.gbm-online.de/mosbach)

In our section RESINS/Mercapto Acids/Thiol Resins:

there are Sulphur carrying building blocks linked through Sulphur to different resin supports. In the case of Amino Thiols the side chains are same as in natural proteinogenic amino acids. The amino group is unprotected and free for any coupling steps via standard SPPS protocols, in order to build up a suitable peptide sequence.
 
After cleavage from the resin (with trifluoroacetate using triethylsilane or ethanedithiol as scavenger) a peptide is being designed, which carries a thiol group on the C-terminus. As sulphur has high affinity to heavy metals, like Zn, Fe or Ni, which are essential metal centers in metallo proteins, the affinity of peptide substrates or pharmacological active sequences can further be increased through a strong sulphur-metal interaction.

H-L-Aha-OH*HCl
H-L-Dab(N3)-OH

4-Azido-L-homoalanine
(S)-2-Amino-4-azidobutanoic acid hydrochloride

Formula:                    C4H8N₄O₂*HCl
Molecular Weight:     144,13*35,45 g/mole

CAS:  942518-29-8

CODE:  HAA5730

1g:       EUR    200,-    US$    300,- 
5g:       EUR    800,-    US$  1200,-

Prices are in EUR, net, exw Germany, shipping not include

Forum Life Sciences 2011

Garching, Germany, Technical University Munich, 23 & 24 March, 2011 (http://www.bayern-innovativ.de)

10th German Peptide Symposium
Freie Universität Berlin

7 March – 10 March, 2011, Berlin, Germany (www.biochemie.tu-berlin.de/10th-gps)

GFPP – 2011
Groupe francais des peptides et des protéines

30 Jan – 4 Feb, 2011, Aussois, France (www.gfpp.free.fr/17_conferenciers)

2nd Int'l Drug Discovery Conference

1.-4. Februray - Dubai, UAE

Mal-AMCHC-OSu

trans-N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate

Formula:                    C16H18N₂O₆
Molecular Weight:     334,33 g/mole

CAS:  64987-85-5

CODE:  MAA1000

1g:       EUR    300,-    US$   420,-
5g:       EUR  1200,-    US$ 1680,-

Prices are in EUR, net, exw Germany, shipping not include