Fmoc-L-Cys(Phacm)-OH – a Green alternative for the synthesis of cyclic peptides

Phacm shows the same stability and orthogonality as Acm and has the additional advantage that it can be deprotected simply by water in the presence of PGA. The addition of co-solvents like acetonitrile helps to improve the solubility of hydrophobic sequences. Water in combination with DMSO (80:20) will make deprotection and cyclization a one pot reaction, which is completed (37°C, pH 7) normally within 16h to 24h.

Find more technical details on our Product News site Green Advantages of using Phacm for Cystein Protection.

Code: FAA6910
Fmoc-L-Cys(Phacm)-OH
CAS: 159680-21-4
C₂₇H₂₆N₂O₅S, 490,57 g/mole
Nα-(9-Fluorenyloxycarbonyl)-
S-(phenylacetylaminomethyl)-L-cysteine

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