Further Information
In conjugation techniques with thiol groups from Cystein or other SH carrying moieties normally maleinimides are used, which react also with other acid protons like for example from OH or NH2 and give appropriate unwanted impurities. The Iodo group reacts much more specifically with thiol resulting in much cleaner conjugates. Reference: Quantitative reactivity profiling predicts functional cysteins in proteomes; K.Weerapana, C.Wang, G.M.Simon, F.Richter, S.Khare, M.B.D.Dillon, D.A.Bachovichin, K.Mowen, D.Baker, B.J.Cravatt; Nature 2010; 468: 790-795.
Details
In conjugation techniques with thiol groups from Cystein or other SH carrying moieties normally maleinimides are used, which react also with other acid protons like for example from OH or NH2 and give appropriate unwanted impurities. The Iodo group reacts much more specifically with thiol resulting in much cleaner conjugates. Reference: Quantitative reactivity profiling predicts functional cysteins in proteomes; K.Weerapana, C.Wang, G.M.Simon, F.Richter, S.Khare, M.B.D.Dillon, D.A.Bachovichin, K.Mowen, D.Baker, B.J.Cravatt; Nature 2010; 468: 790-795.
Additional Information
| ART-NO | PEG3120 |
|---|---|
| DETAIL NAME | alpha-Iodo-omega-propargylacetamido poly(ethylene glycol) (PEG-MW 5000 Dalton) |
| FORMULA | - |
| MOLECULAR WEIGHT | 5000 |
| Bezeichnung Mol Ge | Da |
| QUANTITY | 100 mg |
| neu | J |
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