Visit this regularly updated section to check out the latest additions to our portfolio, as well as the latest developments at Iris Biotech.

  1. Coupling Reagents for Peptide Chemistry

    In this news section, we highlight three useful coupling reagents for peptide chemistry: PyCLOCK, PyAOP and HDMA.

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  2. Triamino Acids

    Fmoc-L-Dap(2-Boc-aminoethyl)-OH is the first in a series of new triamino acid building blocks. This azalysine is useful for introducing positive charges into a peptide, or for creating branched structures.

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  3. Building Blocks for the SPPS of FRET-based fluorogenic protease substrates

    The classic FRET pair EDANS and DABCYL is now available linked to Fmoc amino acid building blocks that can be readily used in SPPS. Conveniently synthesize your own custom protease substrates!

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  4. The Safety-Catch Acid-Labile (SCAL)-Linker

    The SCAL linker offers superior chemical stability and permits a variety of orthogonal solid-phase approaches. It is fully compatible with the Fmoc-, Boc- and Alloc- strategies. Cleavage can be performed either by a simultaneous, or by a two-step reduction/acidolysis procedure to afford peptide amides.

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  5. New Iris Kits for the Synthesis of Peptoids and N-Alkylated Peptides

    Peptides as pharmaceutical compounds suffer from unfavorable pharmacokinetics which is, among other things, due to a slow uptake into cells and rapid proteolytic cleavage. N-Alkylation of peptides is a valuable tool to overcome these limitations. We now offer new kits that enable the facile preparation of peptoids and N-alkylated peptides.

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  6. Chlorotoxin & Biotin-Chlorotoxin

    Chlorotoxin is a chloride channel blocker which has been found in the venom of the Egyptian scorpionLeiurus quinquestriatus. read more
  7. Fast and Easy Protease Kinetics with Asymmetric Rhodamine 110 Substrates

    Asymmetric Rhodamine 110 protease substrates are used for the determination of protease kinetics. The asymmetric structure of these dyes greatly simplifies the determination of enzyme kinetics, while the properties of Rhodamine 110 facilitate an uncomplicated readout.

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  8. THPTA: Ligand-accelerated Click Chemistry in Aqueous Solution

    Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.

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  9. Markers for the Quality of Food

    Maillard Reaction Products (MRPs) result from the reaction of Arg and Lys side chains with reducing carbohydrates. MRPs are valuable markers for food quality and are used in many different branches of industry such as food, pharma, cosmetics and biochemistry.

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  10. Furyl-Alanine: A Novel Photo-Click Amino Acid

    2-Furyl-alanine can be incorporated into peptides via SPPS or by using enzymatic approaches. UV-irradiation in the presence of oxygen and a photosensitizer converts furyl-alanine to an intermediate that selectively reacts with certain nucleophiles. This property can be employed for site-specific labeling of peptides and proteins.

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