Fast & Efficient - from mg to multi-kg - Support & Service
We carry out custom synthesis of complex organic molecules in the domain of our expertise. Non-GMP production from mg to multiple kg can be developed and transferred into GMP environment on demand. Our clients’ typical requirements range from simple one-step reactions to complex multi-step synthesis, with quantities form a few mg, only, to several kg. With qualified contract manufacturing companies we hav...
3. Poly(ethylene glycol) – the Pioneer in Polymer Therapeutics
PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most common known properties.
PEG fragments can be attached to many different positions in a protein. Amino groups of any solvent accessible lysines as well as the N-termini are the most prominent candida...
Conjugates of PEG and folic acid or cholesterol, respectively, combine the positive properties of these molecules. Those conjugates are available with a wide variety of functional groups and different PEG chain lengths to suit your needs.
Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.
Novel liposomes built of dPEG-Phospholipids with defined PEG chain length provide prolonged blood-circulation time and improved cellular uptake as administration carriers for drugs, delivering active molecules to the desired target.