o-Nitroveratryloxycarbonyl (Nvoc) is a photocleavable side chain protecting group for lysine that can be removed by irradiation with UV light (350 nm).
Nvoc is orthogonal to common SPPS conditions, and allows for the selective deprotection of certain lysine epsilon-amino groups for further functionalization or photocaging experiments.
Removal of the Nvoc protecting group by UV light.
See also our product Fmoc-L-Cys(oNv)-OH (FAA3970), where o-nitroveratryl has been used for thiol protection.
→ Order our new booklet on Photochemistry for a comprehensive overview of our photoactivated compounds and their applications.
→ For example, our new Photochemistry booklet describes further applications of the o-nitroveratryl group in drug delivery and photocaging experiments.
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