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News
Visit this regularly updated section to check out the latest additions to our portfolio, as well as the latest developments at Iris Biotech.
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Linkerology® on Metal & Ore Surfaces
A heart of gold! Metals and ores - see here how their surfaces can be equipped with bifunctional organic linker molecules and thus be turned into modifiable biocompatible materials.
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Selective Lysine Labeling with Squaric Acid
Keeping control! PEGylating reagents with a squaric acid ethyl ester react chemoselectively with side chain amino functions of surface-accessible Lysines in proteins. Other functionalities are not affected.
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Process Development – From Discovery to Scale-up
Ongoing research efforts lead to the discovery of innovative building blocks and new APIs. However, for industrial applications, upscaling is required. Herein, we share the process development for Fmoc-Cys(Msbh)-OH.
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Workshop Bioorthogonal Chemistry in the Context of cell-free Protein Synthesis
You missed our workshop featuring Dr. Stefan Kubick (B4Pharmatech, Berlin)? Any further questions? Please get in contact via info@iris-biotech.de
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PotM: Multiconjugates via Simultaneous Double-Click Reaction
Discover our new building block 4-(azido-propyl-tetrazine)phenylalanine (pTAF) and make use of the orthogonality of the 2nd and 3rd generation Click reaction to build multiconjugates via double-Click.
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Conjugating Small Molecule Drugs
You want to attach your small molecule to a certain carrier? Let’s analyze the functional groups present and discuss Linkerology® possibilities for permanent or trigger-inducible, tracelessly-cleavable linkage.
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Cell-Free Bioengineering & Linkerology®
Bioengineering in combination with Linkerology®. Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.
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PotM: TCEP as Versatile Reducing Agent
TCEP is an effective reductant for disulfide bonds and a versatile reagent for various applications in protein science with distinct advantages compared to DTT and BME.
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Conjugating Natural Products (3)
The potential of natural products of daily life, such as 6-shogaol from ginger (Zingiber officinale), can flourish if the active ingredient is conjugated to an appropriate carrier via Linkerology®.
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Functionalization of Carbon Materials by Linker Attachment
Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!
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