SEA Resin [ SEA = bis(2- S ulfanyl E thyl) A mino] is an innovative solid support offering a vast array of tools for efficient synthesis of long peptides through consecutive different ligation technologies performed in a one-pot assembly.
SEA resin is an innovative solid support offering a vast array of tools for efficient synthesis of long peptides.
SEA resin yields SEA peptides which can be ligated directly with Cys peptides using SEA native peptide ligation.
SEA resin gives easy acces...
Jan Spengler, Christoph Böttcher, Fernando Albericio, and Klaus Burger
Chem. Rev. 2006; 106:4728-4746
Abstract: A considerable number of biologically active naturally occurring products are peptides, depsipeptides, and peptide conjugates. Peptide modification can be performed by backbone modification and modification of the substituent pattern of the side-chain of the monomers. Direct therapeutic applications of native peptides are limited. However, major drawbacks of peptide drugs, lik...
Pavel S. Chelushkin, Ksenia V. Polyanichko, Maria V. Leko, Marina Yu. Dorosh, Thomas Bruckdorfer and Sergey V. Burov
Tetrahedron Letters 2015; 56 : 619–622; DOI: 10.1016/j.tetlet.2014.12.056
Abstract: Peptide hydrazides can be easily synthesized using a new hydrazone resin, obtained via acylation of aminomethyl polystyrene by Fmoc-hydrazone of pyruvic acid. It was shown that the hydrazone linker is completely stable in the course of standard Fmoc SPPS. Moreover, it can tolerate a tre...