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Fmoc-L-Mim-OH
Chemischer Name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-mimosine // Synonyme: Fmoc-Mim-OH, (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid
- Art-Nr.:FAA3520
- CAS Nr.:1271936-31-2
- Formel:C23H20N2O6
- Molare Masse:420,41 g/mol
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description
Natural Mimosine extracted from Leucaena leucocephala de Wit is a sustainable starting material for development of drugs or cosmetics. Mimosine inhibits tyrosinase, cycloxygenase and lipoxygenase thus cosmetic application for whitening is one of the big interests. Hydroxy keton derivatives (like mimosine) induce apoptosis and have potential as anti-tumor agents. Mim exhibits no significant cytotoxicity nor acute dermal toxicity. This building block opens the field to use mimosine in peptides or organic molecules as key fragment and equip the drug molecule with the mimosine specific properties.
references
Natural Mimosine extracted from Leucaena leucocephala de Wit is a sustainable starting material for development of drugs or cosmetics. Mimosine inhibits tyrosinase, cycloxygenase
and lipoxygenase thus cosmetic application for whitening is one of the big interests. Hydroxy keton derivatives (like mimosine) induce apoptosis and have potential as anti-tumor
agents. Mim exhibits no significant cytotoxicity nor acute dermal toxicity. This building block opens the field to use mimosine in peptides or organic molecules as key fragment
and equip the drug molecule with the mimosine specific properties.
References:
Nokihara, K, et.al., Preparative scale isolation, purification and derivatization of mimosine, a non-proteinogenic amino acid; Amino Acids 2011; Published online 13 Oct 2011. DOI
10.1007/s00726-011-1104-y.
Nokihara, K, et.al., A Non-proteinogenic Amino Acid, Mimosine and Mimosyl Peptides for Cosmeceutical Ingredients; Peptide Science 2010, The Japanese Peptide Society 2011, 282.
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