Fmoc-L-Cys(Msbh)-OH

Chemischer Name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-(4,4'-dimethylsulfinylbenzhydryl)-L-cysteine // Synonyme: Fmoc-Cys(Msbh)-OH, (2R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(bis(4-(methylsulfinyl)phenyl)methylthio)propanoic acid, Safety-Catch L-Cysteine

  • Art-Nr.:FAA4155
  • CAS Nr.:1584646-97-8
  • Formel:C33H31NO6S3
  • Molare Masse:633,80 g/mol

Startet von 90,00 €

Gruppiert Produkte - Artikel
Anzahl Verpackungsgröße Preis SKU
250 mg
90,00 €
FAA4155.0250
1 g
250,00 €
FAA4155.1000
5 g
1.000,00 €
FAA4155.5000
Sicherheitsdatenblätter
description

MsbH is a safety-catch protecting group for cysteines, serines and threonines. It is stable to the conditions applied in both Boc and Fmoc chemistry. By reduction of the sulfoxides to thioethers with NH4I and dimethylsulfide in TFA, the MsbH protection becomes instable and is instantly removed.



references

Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4'-Dimethylsulfinylbenzhydryl; Zoltan Dekan, Mehdi Mobli, Michael W. Pennington, Eileen Fung, Elizabeta Nemeth, and Paul F. Alewood; Angew. Chem. Int. Ed. 2014; 53: 2931-2934. DOI: 10.1002/anie.201310103.

A new safety-catch protecting group and linker for solid-phase synthesis. Sathiah Thennarasu, Chuan-Fa Liu; Tetrahedron Lett. 2010; 51(24): 3218-3220. DOI: 10.1016/j.tetlet.2010.04.047.

A Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis Based on Safety-Catch Protection. Tooru Kimura, Toshio Fukui, Shigeki Tanaka, Kenichi Akaji, Yoshiaki Kiso; Chem. Pharm. Bull. 1997; 45: 18-26. DOI: 10.1248/cpb.45.18.

Safety-catch anchoring linkage for synthesis of peptide amides by Boc/Fmoc strategy. Marcel Pátek, Michal Lebl; Tetrahedron Lett. 1991; 32(31): 3891-3894. DOI: 10.1016/S0040-4039(00)79406-8.

The p-(methylsulfinyl)benzyl group: a trifluoroacetic acid (TFA)-stable carboxyl-protecting group readily convertible to a TFA-labile group. James M. Samanen, Ester Brandeis; J. Org. Chem. 1988; 53(3): 561-569. DOI: 10.1021/jo00238a016.


Bulk oder Großmengen-Bestellung?

Sie benötigen größere Mengen für Ihre Entwicklung oder Produktion?

Benötigen Sie weitere Informationen über dieses Produkt?

kontaktieren Sie uns

Schneller Kontakt

Bitte senden Sie mir mehr Informationen über

Produkte, die Sie auch interessieren könnten!