2-Oxo-L-histidine

Chemical name: (S)-2-amino-3-(2-oxo-2,3-dihydro-1H-imidazol-4-yl)propanoic acid // Synonyms: 2-oxohistidine

Art-No.:HAA4060
Cas-no.:171483-23-1
Formula:C6H9N3O3
Molecular weight:171,15 g/mol
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description
Histidine is one of the major oxidation targets due to its metal'2dchelating property and susceptibility to metal'2dcatalyzed oxidation. The major product of histidine oxidation, 2-oxohistidine, has been identified as a stable marker of oxidative damage in biological system, associated with aging and neurodegenerative disorders. Peptide probes and peptide antigens containing 2'2doxohistidine will help to advance the study of non'2denzymatic posttranslational modification.

references
Reference:

Synthesis of peptides containing 2'2doxohistidine residues and their characterization by liquid chromatography'2dtandem mass spectrometry; Che'2dFan Huang, Yu'2dHsuan Liu, Hwan'2dChing Tai; J. Pept. Sci. 2015; 21: 114-119. DOI: org/10.1002/psc.2735.

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