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L-Thioarginine
Chemischer Name: (2S)-2-amino-5-(carbamimidoylsulfanyl)pentanoic acid hydrochloride salt // Synonyme: (S)-2-amino-5-(carbamimidoylthio)pentanoic acid hydrochloride salt, Thioarginine*HCl
- Art-Nr.:HAA9165
- CAS Nr.:190374-70-0
- Formel:C6H13N3O2S
- Molare Masse:191,25 g/mol
Startet von 200,00 €
description
Maillard Reaction Products (MRPs) are indicators for the heat treatment of food, as well as markers of nutritional quality. They also appear naturally in the human body as so-called Advanced Glycation End Products (AGEs). As such, they are indicators for body health and disease processes, including inflammation, diabetes, cancer and ageing. Consequently, AGEs gained broad attention in cosmetics, biochemistry, food, and pharmaceutical applications.
This material is supplied as a salt containing varying contents of the acid counterion. The net content of each batch is specified in the respective certificate of analysis.
Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with N-omega-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. Thioarginine is a colorimetric substrate for arginase that provides the basis for continuous spectrophotometric measurement of enzyme activity. It exhibits Km and kcat values of 0.5 mM and 18,000 min-1, respectively, which are similar to physiological substrate arginine. The thiol product of the reaction reacts with DTNB to produce 2-nitro-5-thiobenzoate for easy visualization at 405-420 nm.
references
Amino acid discrimination by arginyl-tRNA synthetases as revealed by an examination of natural specificity variants; G. L. Igloi and E. Schiefermayr; FEBS J 2009; 276: 1307-18. https://doi.org/10.1111/j.1742-4658.2009.06866.x
Synthesis and evaluation of alternative substrates for arginase; S. Han, R. A. Moore and R. E. Viola; Bioorg Chem 2002; 30: 81-94. https://doi.org/10.1006/bioo.2001.1228
A spectrophotometric assay of arginase; S. Han and R. E. Viola; Anal Biochem 2001; 295: 117-9. https://doi.org/10.1006/abio.2001.5189
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