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Anthony Romieu, Thomas Bruckdorfer, Guillaume Clavé, Virgile Grandclaude, Cédrik Massif and Pierre-Yves Renard
Org. Biomol. Chem.2011; 9:5337. DOI: 10.1039/c1ob05730h
Abstract: An easy and efficient solid-phase synthesis strategy to obtain rapidly water-soluble chromophores/fluorophores in highly pure form has been developed. This first successful use of N-Fmoc-alpha-sulfo-beta-alanine as a SPPS building block opens the way to the future development of promising direct “on-resin” peptide labeling and water-solubilizing methods.