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Several platforms are available to display the whole assortment of homo-amino acids, as well as the higher homologues β2-, β3-, their double substituted derivatives β2,2,2-, β3,3-, and corresponding γ-amino acids. Using e.g. via 4-benzyloxazolidin-2-one templates and using specific conformation of the chiral benzyl residue each conformation of a β2-analogue can precisely be addressed.
The variation and possibilities become even more diverse with GABA (γ-amino butyric acid) as scaffold. Our platform allows using any available amino acid as starting material and transform them into the corresponding Statine-analogue.
Templates of homo- β2-, β3-, and γ-amino acids and possible Statine analogues.
Examples of possible double substituted derivatives of β2,2- and β3,3-amino acids.