ICG-E[c(RGDfK)]2

Chemischer Name: N-alpha-(indocyanine green)-bis[cyclo[arginyl-glycyl-aspartyl-D-phenylalanyl-lysyl]] glutamate // Synonyme: ICG-E[cyclo(RGDfK)]2, ICG-E[cyclo(RGDfK)]-cyclo(RGDfK), N-alpha-(indocyanine green)-bis[cyclo[arginyl-glycyl-aspartyl-D-phenylalanyl-lysyl]] glutamate

  • Art-Nr.:LS-3950
  • Formel:C104H135N21O20S
  • Molare Masse:2031,38 g/mol

Startet von 245,00 €

Gruppiert Produkte - Artikel
Anzahl Verpackungsgröße Preis SKU
auf Anfrage auf Anfrage auf Anfrage LS-3950.0000
Sicherheitsdatenblätter
description

This is an ICG conjugate of LS-3980 (E[c(RGDfK)]c(RGDfK)), a cyclic RGD peptide, which shows high tumor targeting properties. It is an integrin inhibitor and gained interest non-small-cell lung cancer treatment. This compound is soluble in DMSO and DMSO/water mixtures.

 


references

1. Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model. Marcel L. Janssen, Wim J. Oyen, Ingrid Dijkgraaf, Leon F. Massuger, Cathelijne Frielink, D. Scott Edwards, Milind Rajopadhye, Henk Boonstra, Frans H. Corstens and Otto C. Boerman; Cancer Res. 2002; 62(21): 6146-6151.

2. microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide. Yun Wu, Xianzhong Zhang, Zhengming Xiong, Zhen Cheng, Darrell R. Fisher, Shuang Liu, Sanjiv S. Gambhir, and Xiaoyuan Chen; J. Nucl. Med. 2005; 46(10): 1707-1718.

 

References for similar peptides:

1. Radiolabeled Cyclic RGD Peptides as Radiotracers for Imaging Tumors and Thrombosis by SPECT. Yang Zhou, Sudipta Chakraborty, and Shuang Liu;

Theranostics 2011; 1: 58–82.

2. Jytte Oxboel et al., Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and 64Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors, Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and (64)Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors. Jytte Oxboela, Malene Brandt-Larsen, Christina Schjoeth-Eskesen, Rebecca Myschetzky, Henrik H. El-Ali, Jacob Madsen, Andreas Kjaer; Nuclear Medicine and Biology 2014; 41(3): 259-267.

DOI: 10.1016/j.nucmedbio.2013.12.003.

3. Stability Analysis of Glutamic Acid Linked Peptides Coupled to NOTA through Different Chemical Linkages. Lixin Lang, Ying Ma, Dale O. Kiesewetter, and Xiaoyuan Chen; Mol. Pharm. 2014; 11(11): 3867–3874. DOI: 10.1021/mp400706q.


Bulk oder Großmengen-Bestellung?

Sie benötigen größere Mengen für Ihre Entwicklung oder Produktion?

Benötigen Sie weitere Informationen über dieses Produkt?

kontaktieren Sie uns

Schneller Kontakt

Bitte senden Sie mir mehr Informationen über

Produkte, die Sie auch interessieren könnten!