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Compounds with lupane structure typically exhibit limited solubility in organic solvents suc h as methanol and ethanol, chloroform, and ether and has low solubility in water, petroleum ether, dimethyl formamide, dimethyl sulfoxide, and benzene. However, they are normally highly soluble in pyridine and acetic acid.
Design, Synthesis, and Evaluation of Novel 1,2,3-Triazole-Tethered Glycolipids as Vaccine Adjuvants; Debabrata Bhunia, Preethi M. C. Pallavi, Srinivasa Reddy Bonam, Sandeep A. Reddy, Yogesh Verma, and M. Sampath Kumar Halmuthur; Arch. Pharm. Chem. Life Sci. 2015; 348: 689–703. DOI: 10.1002/ardp.201500143.
Betulin and its derivatives as novel compounds with different pharmacological effects; Shayan Amiri, Sanaz Dastghaib, Mazaher Ahmadi, Parvaneh Mehrbod, Forough Khadem, Hamid Behrouj, Mohamad-Reza Aghanoori, Filip Machaj, Mahdi Ghamsari, Jakub Rosik, Andrzej Hudecki, Abbas Afkhami, Mohammad Hashemi, Marek J. Losj, Pooneh Mokarram, Tayyebeh Madrakian, Saeid Ghavami; Biotechnology Advances 2019: DOI: org/10.1016/j.biotechadv.2019.06.008.
Structural modifications of 2,3-indolobetulinic acid: design and synthesis of highly potent -glucosidase inhibitors; Elmira F. Khusnutdinova, Anastasiya V. Petrova, Ha Nguyen Thi Thu, Anh Le Thi Tu, Tra Nguyen Thanh, Cham Ba Thi, Denis A. Babkov, Oxana B. Kazakova; Bioorganic Chemistry 2019; 88: 102957. DOI: org/10.1016/j.bioorg.2019.102957.
Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivatives; Vivek Kumar, Nidhi Rani, Pawan Aggarwal, Vinod K. Sanna, Anu T. Singh, Manu Jaggi, Narendra Joshi, Pramod K. Sharma, Raghuveer Irchhaiya, Anand C. Burman; Bioorg. Med. Chem. Lett. 2008; 18: 5058–5062. DOI: 10.1016/j.bmcl.2008.08.003.
Synthesis and cytotoxic evaluation of novel amide-triazole-linked triterpenoid-AZT conjugates; Tuyet Anh Dang Thi, Nguyen Thi Kim Tuyet, Chinh Pham The, Ha Thanh Nguyen, Cham Ba Thi, Hoang Thi Phuong, Luu Van Boi, Tuyen Van Nguyen, Matthias D’hooghe; Tet. Lett. 2015; 56(1): 218-224. DOI: org/10.1016/j.tetlet.2014.11.069.
Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugates; Pathi Suman, Amardeep Patel, Lucas Solano, Gayathri Jampana, Zachary S. Gardner, Crystal M. Holt, Subash C. Jonnalagadda; Tetrahedron 2017; 73: 4214-4226. DOI: org/10.1016/j.tet.2016.11.056.
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