Name: Mal-D-Dap(Boc)-OH*DCHA
SKU: MAA1060
Availability: InStock

Gruppiert Produkte - Artikel

Anzahl

Verpackungsgröße

Preis

SKU

100 mg

90,00 €

MAA1060.0100

250 mg

150,00 €

MAA1060.0250

500 mg

270,00 €

MAA1060.0500

1 g

420,00 €

MAA1060.1000

5 g

1.500,00 €

MAA1060.5000

Sicherheitsdatenblätter

description

Building block, which can be used for conjugation with thiol groups. After removal of the Boc protecting group and conjugation with the mercaptane function the free methylamino side chain will open the maleimide ring under aqueous conditions. While the conjugation reaction between thiol and maleimid is reversible, it turns completely stable in the open ring structure. This becomes particularly important in the formation of conjugates with high value components, like in antibody-drug conjugation (ADC).

references

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates; R.P. Lyon, J.R. Setter, T.D. Bovee, S.O. Doronia, J.H. Hunter, M.E.

Anderson, C.L.Balasubramanian, S.M. Duniho, C.I. Leiske, F. Li, P.D. Senter; Nature Biotechnology. 2014; 32(10): 1059-1062. Doi:10.1038/nbt.2968.