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N3Ac-OPhOMe
Chemischer Name: 4-Methoxyphenyl 2-azidoacetate
- Art-Nr.:RL-3010
- CAS Nr.:2546513-31-7
- Formel:C9H9N3O3
- Molare Masse:207,19 g/mol
Startet von 225,00 €
description
Methodology for highly selective N-terminal chemical acylation of expressed proteins. This 4-methoxyphenyl ester adds selectively to Gly-His-tags of proteins, while it does not react with epsilon amino functions of surface accessible lysines. Therefore, it expresses a unique possibility to label proteins regiospecific at the Gly-His tag position, enabling a wide application field in chemical biology and for biopharmaceuticals.
references
Selective N-terminal acylation of peptides and proteins with a Gly-His tag sequence; Manuel C. Martos-Maldonado, Christian T. Hjuler, Kasper K. Sørensen, Mikkel B. Thygesen, Jakob E. Rasmussen, Klaus Villadsen, Søren R. Midtgaard, Stefan Kol, Sanne Schoffelen, and Knud J. Jensen; Nature Communications 2018; 9: 3307. DOI: 10.1038/s41467-018-05695-3
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News Product of the month Life SciencesPotM: His Tags for the Chemical Modification of Peptides
Jensen et al. developed two methods that use poly-His sequences to direct the highly selective acylation of proteins, either at the N-term
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