Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
USD
Quick contact
Please send me more information about
N-Acetyltryptamine
Chemical name: N-[2-(1H-indol-3-yl)ethyl]-acetamide // Synonyms: 3-(2-N-Acetylaminoethyl)indole; N-acetyl tryptamine
- Product code:ANN1000
- CAS No.:1016-47-3
- Formula:C12H14N2O
- Molecular weight:202.25 g/mol
Starting at $195.00
description
A structural analog of melatonin that binds the melatonin MT2 receptor (Ki = 0.41 nM). It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina. N-acetyl tryptamine also is a reaction product of assays for serotonin N-acetyltransferase in the melatonin biosynthetic pathway.
references
Melatonin receptor pharmacology: Toward subtype specificity; D. Sugden, H. Pickering, M.T. Teh, et al.; Biol. Cell 1997; 89(8): 531-537.
Characterization of a retinal melatonin receptor; M.L. Dubocovich; J. Pharmacol. Exp. Ther. 1985; 234(2): 395-401.
Ligand efficacy and potency at recombinant human MT2 melatonin receptors: Evidence for agonist activity of some mt1-antagonists; R. Nonno, M. Pannacci, V. Lucini et al.; Br. J. Pharmacol. 2016; 127(5): 1288-1294.
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Dubocovich, M.L., Masana, M.I., Iacob, S., et al.; Naunyn Schmiedebergs Arch. Pharmacol. 1997; 355(3): 365-375.
Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87). DeAngelis, J., Gastel, J., Klein, D.C., et al.; J. Biol. Chem. 1998; 273(5): 3045-3050.
Bulk or large quantity order?
Do you need larger quantities for your development or production?
Do you need further information about this product?
get in contact
Related Products
We found other products you might like!
