Boc-beta,beta-diMe-D-Ser-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-beta,beta-dimethyl-D-serine // Synonyms: Boc-D-Hvl-OH, (R)-Boc-beta-hydroxy-valine, (R)-Boc-2-amino-3-hydroxy-3-methyl-butyric acid, (R)-Boc-beta,beta-dimethyl-serine, (R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-methylbutanoic acid

Product code:BAA2850
CAS No.:288159-40-0
Formula:C10H19NO5
Molecular weight:233,26 g/mol
Grouped product items
Qty Packing unit Price SKU
5 g
$1,856.25
BAA2850.0005
25 g
$4,185.00
BAA2850.0025
description

beta,beta-Dimethylation of amino acids stabilizes appropriate peptides towards digestion by proteases. The hydroxyl function of this serine building block is unprotected, because acylation does not happen to tertiary alcohols during standard Boc/Bzl coupling protocols.


references

A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates; Kathryn R. Heard, Wengen Wu, Youhua Li, Peng Zhao, Iwona Woznica, Jack H. Lai, Martin Beinborn, David G. Sanford, Matthew T. Dimare, Amrita K. Chiluwal, Diane E. Peters, Danielle Whicher, James L. Sudmeier, and William W. Bachovchin; J. Med. Chem. 2013; 56: 8339−8351. dx.doi.org/10.1021/jm400423p.

Total synthesis of the large non-ribosomal peptide polytheonamide B; Masayuki Inoue, Naoki Shinohara, Shintaro Tanabe, Tomoaki Takahashi, Ken Okura,Hiroaki Itoh, Yuki Mizoguchi, Maiko Iida, Nayoung Lee and Shigeru Matsuoka; Nature Chem. 2010; 2: 281-285. DOI: 10.1038/nchem.554.

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information of this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!
Structure image for Fmoc-L-Ser(tBu)-OH
Fmoc-L-Ser(tBu)-OH

Starting at $67.50

Structure image for H-L-Ser(tBu)-OMe*HCl
H-L-Ser(tBu)-OMe*HCl

Starting at $135.00

Structure image for Boc-L-Ser(Bzl)-OH
Boc-L-Ser(Bzl)-OH

Starting at $54.00

Structure image for Boc-D-Ser(Bzl)-OH
Boc-D-Ser(Bzl)-OH

Starting at $189.00

Structure image for Boc-L-Ser-OH
Boc-L-Ser-OH

Starting at $94.50

Structure image for Fmoc-L-Ser(Me)-OH
Fmoc-L-Ser(Me)-OH

Starting at $310.50

Structure image for Trt-L-Ser-OH*TEA
Trt-L-Ser-OH*TEA

Starting at Please inquire

Structure image for Fmoc-L-Ser-OH
Fmoc-L-Ser-OH

Starting at $155.25

Structure image for Boc-L-Ser(tBu)-OH
Boc-L-Ser(tBu)-OH

Starting at $189.00

Structure image for H-D-Ser(tBu)-OMe*HCl
H-D-Ser(tBu)-OMe*HCl

Starting at $121.50

Structure image for Fmoc-L-Ser(Trt)-OH
Fmoc-L-Ser(Trt)-OH

Starting at $67.50

Structure image for Fmoc-D-Ser(tBu)-OH
Fmoc-D-Ser(tBu)-OH

Starting at $94.50

Structure image for Fmoc-D-Ser(Trt)-OH
Fmoc-D-Ser(Trt)-OH

Starting at $135.00

Structure image for Trt-D-Ser-OH*TEA
Trt-D-Ser-OH*TEA

Starting at Please inquire

Structure image for Fmoc-L-Ser(beta-D-GlcAc4)-OH
Fmoc-L-Ser(beta-D-GlcAc4)-OH

Starting at $796.50

Structure image for H-L-Ser(tBu)-OtBu*HCl
H-L-Ser(tBu)-OtBu*HCl

Starting at $216.00

Structure image for Fmoc-L-Ser(Bzl)-OH
Fmoc-L-Ser(Bzl)-OH

Starting at $60.75

Structure image for Fmoc-D-Ser(Me)-OH
Fmoc-D-Ser(Me)-OH

Starting at $135.00

Structure image for Boc-L-Ser-OBzl
Boc-L-Ser-OBzl

Starting at $371.25

Structure image for Fmoc-L-Ser(PO(OBzl)OH)-OH
Fmoc-L-Ser(PO(OBzl)OH)-OH

Starting at $202.50

Structure image for Ac-L-Ser(tBu)-OH
Ac-L-Ser(tBu)-OH

Starting at $168.75

Structure image for Fmoc-L-Ser(TF)-OH
Fmoc-L-Ser(TF)-OH

Starting at $1,282.50

Structure image for Bzl-L-Ser(Bzl)-OMe*(COOH)2
Bzl-L-Ser(Bzl)-OMe*(COOH)2

Starting at $337.50

Structure image for Bzl-L-Ser(tBu)-OMe*HCl
Bzl-L-Ser(tBu)-OMe*HCl

Starting at $405.00

Structure image for Boc-D-Ser-OH
Boc-D-Ser-OH

Starting at $94.50

Structure image for Boc-L-Ser(Trt)-OH
Boc-L-Ser(Trt)-OH

Starting at $162.00

Structure image for Boc-D-Ser(Me)-OH*DCHA
Boc-D-Ser(Me)-OH*DCHA

Starting at $378.00

Structure image for Boc-L-Ser(Me)-OH*DCHA
Boc-L-Ser(Me)-OH*DCHA

Starting at $229.50

Structure image for Boc-L-Ser-OMe
Boc-L-Ser-OMe

Starting at $155.25

Structure image for Boc-L-Ser(Bzl)-NMe(OMe)
Boc-L-Ser(Bzl)-NMe(OMe)

Starting at $87.75

Structure image for Boc-L-Ser(Bzl)-OSu
Boc-L-Ser(Bzl)-OSu

Starting at $101.25

Structure image for Fmoc-D-Ser(Bzl)-OH
Fmoc-D-Ser(Bzl)-OH

Starting at $189.00

Structure image for Fmoc-D-Ser-OH*H2O
Fmoc-D-Ser-OH*H2O

Starting at $87.75

Structure image for Fmoc-L-Ser-OBzl
Fmoc-L-Ser-OBzl

Starting at Please inquire

Structure image for Fmoc-L-Ser(TBDMS)-OH
Fmoc-L-Ser(TBDMS)-OH

Starting at $202.50

Structure image for Fmoc-L-Ser(STn)-OH
Fmoc-L-Ser(STn)-OH

Starting at Please inquire

Structure image for H-D-Ser(Bzl)-OH*HCl
H-D-Ser(Bzl)-OH*HCl

Starting at $168.75

Structure image for H-D-Ser(tBu)-OH
H-D-Ser(tBu)-OH

Starting at $114.75

Structure image for H-D-Ser(tBu)-OtBu*HCl
H-D-Ser(tBu)-OtBu*HCl

Starting at $128.25

Structure image for H-L-Ser(tBu)-OH
H-L-Ser(tBu)-OH

Starting at $175.50

Structure image for Trt-D-Ser(Bzl)-OH*DEA
Trt-D-Ser(Bzl)-OH*DEA

Starting at Please inquire

Structure image for Trt-L-Ser(Bzl)-OH*DEA
Trt-L-Ser(Bzl)-OH*DEA

Starting at Please inquire

Structure image for Z-L-Ser-OH
Z-L-Ser-OH

Starting at $94.50

Structure image for Boc-L-Ser(Propargyl)-OH*DCHA
Boc-L-Ser(Propargyl)-OH*DCHA

Starting at $270.00

Structure image for Fmoc-L-Ser(Propargyl)-OH
Fmoc-L-Ser(Propargyl)-OH

Starting at $270.00

Structure image for Fmoc-L-Ser(alpha-Fuc(Ac3))-OH
Fmoc-L-Ser(alpha-Fuc(Ac3))-OH

Starting at $1,275.75

Structure image for Boc-beta,beta-diMe-L-Ser-OH
Boc-beta,beta-diMe-L-Ser-OH

Starting at $135.00

Structure image for H-L-Ser(Propargyl)-OH*HCl
H-L-Ser(Propargyl)-OH*HCl

Starting at $270.00

Structure image for Fmoc-beta,beta-diMe-L-Ser-OH
Fmoc-beta,beta-diMe-L-Ser-OH

Starting at $135.00

Structure image for Fmoc-beta,beta-diMe-D-Ser-OH
Fmoc-beta,beta-diMe-D-Ser-OH

Starting at $1,856.25

Structure image for Fmoc-alpha-Me-L-Ser(tBu)-OH
Fmoc-alpha-Me-L-Ser(tBu)-OH

Starting at Please inquire

Structure image for Fmoc-L-Ser(decyl)-OH
Fmoc-L-Ser(decyl)-OH

Starting at Please inquire

Structure image for Fmoc-L-Pma(tBu)2-OH
Fmoc-L-Pma(tBu)2-OH

Starting at $337.50

Structure image for Aloc-L-Ser(tBu)-OH*DCHA
Aloc-L-Ser(tBu)-OH*DCHA

Starting at $553.50

Structure image for H-L-Ser(tBu)-NH2*AcOH
H-L-Ser(tBu)-NH2*AcOH

Starting at $999.00

Structure image for H-L-Ser(Trt)-OH
H-L-Ser(Trt)-OH

Starting at $553.50

Structure image for Boc-homo-beta-2-Hydoxyvaline
Boc-homo-beta-2-Hydoxyvaline

Starting at $337.50

Boc-L-Ser(Ph)-OH
Boc-L-Ser(Ph)-OH

Starting at Please inquire

Fmoc-L-Ser(Ph)-OH
Fmoc-L-Ser(Ph)-OH

Starting at Please inquire

Boc-L-Ser(cHx)-OH
Boc-L-Ser(cHx)-OH

Starting at Please inquire

Fmoc-L-Ser(cHx)-OH
Fmoc-L-Ser(cHx)-OH

Starting at Please inquire

Structure image for Boc-L-Ser(CF3)-OH
Boc-L-Ser(CF3)-OH

Starting at Please inquire

Structure image for Fmoc-L-Ser(CF3)-OH
Fmoc-L-Ser(CF3)-OH

Starting at Please inquire

Structure image for Boc-L-Ser(CF2H)-OH
Boc-L-Ser(CF2H)-OH

Starting at Please inquire

Structure image for Fmoc-L-Ser(CF2H)-OH
Fmoc-L-Ser(CF2H)-OH

Starting at Please inquire