Boc-L-Pro(4-OCF3)-OH (2S,4R)

Chemical name: (2S,4R)-1-(tert-butoxycarbonyl)-4-(trifluoromethoxy)pyrrolidine-2-carboxylic acid // Synonyms: Boc-Pro(4-OCF3)-OH (2S,4R)

  • Product code:BAA4390
  • Formula:C11H16F3NO5
  • Molecular weight:299,25 g/mol

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references

The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L; E. Buommino, A. Carotenuto, I. Antignano, R. Bellavita, B. Casciaro, M. R. Loffredo, F. Merlino, E. Novellino, M. L. Mangoni, F. P. Nocera, D. Brancaccio, P. Punzi, D. Roversi, R. Ingenito, E. Bianchi and P. Grieco; ChemMedChem 2019; 14: 1283-1290. https://doi.org/10.1002/cmdc.201900221

Comparative effects of trifluoromethyl- and methyl-group substitutions in proline; V. Kubyshkin, S. Pridma and N. Budisa; New Journal of Chemistry 2018; 42: 13461-13470. https://doi.org/10.1039/c8nj02631a

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode; E. A. Jurica, X. Wu, K. N. Williams, A. S. Hernandez, D. S. Nirschl, R. A. Rampulla, A. Mathur, M. Zhou, G. Cao, C. Xie, B. Jacob, H. Cai, T. Wang, B. J. Murphy, H. Liu, C. Xu, L. K. Kunselman, M. B. Hicks, Q. Sun, D. M. Schnur, D. F. Sitkoff, E. A. Dierks, A. Apedo, D. B. Moore, K. A. Foster, M. E. Cvijic, R. Panemangalore, N. A. Flynn, B. D. Maxwell, Y. Hong, Y. Tian, J. J. Wilkes, B. A. Zinker, J. M. Whaley, J. C. Barrish, J. A. Robl, W. R. Ewing and B. A. Ellsworth; Journal of medicinal chemistry 2017; 60: 1417-1431. https://doi.org/10.1021/acs.jmedchem.6b01559

gamma-(S)-Trifluoromethyl proline: evaluation as a structural substitute of proline for solid state (19)F-NMR peptide studies; V. Kubyshkin, S. Afonin, S. Kara, N. Budisa, P. K. Mykhailiuk and A. S. Ulrich; Org Biomol Chem 2015; 13: 3171-3181. https://doi.org/10.1039/c5ob00034c

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