Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying though a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.Continue to Iris Biotech GmbHSend request to US distributor
Chemical name: N-alpha-t-Butyloxycarbonyl-5,5,5,5’,5’,5’-hexafluoro-L-leucine // Synonyms: (S)-Boc-2-amino-5,5,5-trifuoro-4-(trifluoromethyl)pentanoic acid, Boc-L-5,5,5,5’,5’,5’-hexafluoroleucine, Boc-L-Leu(F6)-OH, Boc-L-hexafluoroleucine, Boc-hexafluoroleucine, (S)-2-((tert-butoxycarbonyl)amino)-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid
|Molecular weight:||339,23 g/mol|
Effects of single substitutions with hexafluoroleucine and trifluorovaline on the hydrophobic core formation of a heterodimeric coiled coil; S. Huhmann, E. K. Nyakatura, H. Erdbrink, U. I. M. Gerling, C. Czekelius and B. Koksch; Journal of Fluorine Chemistry 2015; 175: 32-35. https://doi.org/10.1016/j.jfluchem.2015.03.003
Fluorinated proteins: from design and synthesis to structure and stability; E. N. Marsh; Acc Chem Res 2014; 47: 2878-86. https://doi.org/10.1021/ar500125m
Cross-strand interactions of fluorinated amino acids in beta-hairpin constructs; G. A. Clark, J. D. Baleja and K. Kumar; J Am Chem Soc 2012; 134: 17912-21. https://doi.org/10.1021/ja212080f
Influence of fluorination on the thermodynamics of protein folding; B. C. Buer, B. J. Levin and E. N. Marsh; J Am Chem Soc 2012; 134: 13027-34. https://doi.org/10.1021/ja303521h
Effect of highly fluorinated amino acids on protein stability at a solvent-exposed position on an internal strand of protein G B1 domain; H. P. Chiu, B. Kokona, R. Fairman and R. P. Cheng; J Am Chem Soc 2009; 131: 13192-3. https://doi.org/10.1021/ja903631h
Influence of selective fluorination on the biological activity and proteolytic stability of glucagon-like peptide-1; H. Meng, S. T. Krishnaji, M. Beinborn and K. Kumar; Journal of medicinal chemistry 2008; 51: 7303-7. https://doi.org/10.1021/jm8008579
Using fluorous amino acids to modulate the biological activity of an antimicrobial peptide; L. M. Gottler, H. Y. Lee, C. E. Shelburne, A. Ramamoorthy and E. N. Marsh; Chembiochem : a European journal of chemical biology 2008; 9: 370-3. https://doi.org/10.1002/cbic.200700643
Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine; H. Y. Lee, K. H. Lee, H. M. Al-Hashimi and E. N. Marsh; J Am Chem Soc 2006; 128: 337-43. https://doi.org/10.1021/ja0563410
Helix propensity of highly fluorinated amino acids; H. P. Chiu, Y. Suzuki, D. Gullickson, R. Ahmad, B. Kokona, R. Fairman and R. P. Cheng; J Am Chem Soc 2006; 128: 15556-7. https://doi.org/10.1021/ja0640445
Synthesis and thermodynamic characterization of self-sorting coiled coils; B. Bilgiçer and K. Kumar; Tetrahedron 2002; 58: 4105-4112. https://doi.org/10.1016/s0040-4020(02)00260-0
Biosynthesis of a highly stable coiled-coil protein containing hexafluoroleucine in an engineered bacterial host; Y. Tang and D. A. Tirrell; J Am Chem Soc 2001; 123: 11089-90. https://doi.org/10.1021/ja016652k
Programmed self-sorting of coiled coils with leucine and hexafluoroleucine cores; B. Bilgicer, X. Xing and K. Kumar; J Am Chem Soc 2001; 123: 11815-6. https://doi.org/10.1021/ja016767o
Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability; Y. Tang, G. Ghirlanda, W. A. Petka, T. Nakajima, W. F. DeGrado and D. A. Tirrell; Angewandte Chemie International Edition 2001; 40: 1494-1496. https://doi.org/10.1002/1521-3773(20010417)40:8<1494::Aid-anie1494>3.0.Co;2-x
Do you need larger quantities for your development or production?
Please send me more information about