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Chemical name: N-alpha-t-Butyloxycarbonyl-3-ethyl-3-methyl-L-Norvaline // Synonyms: (S)-2-((tert-butoxycarbonyl)amino)-3-ethyl-3-methylpentanoic acid, N-[1,1-dimethylethoxy)carbonyl]3-ethyl-3-methyl-L-Norvaline, Boc-3-ethyl-3-methyl-L-norvaline, Boc-3-ethyl-3-methyl-Nva-OH, Boc-3-ethyl-3-methyl-L-Nva-OH, Boc-Nva(3-Et-3-Me)-OH
|Molecular weight:||259,35 g/mol|
Iris Biotech offers various Nva derivatives with different sterical and electronical properties, which can be incorporated into peptides for the investigation of structure activity relationships and lead optimization. Furthermore, Norvaline and its derivatives can be incorporated into peptides as surrogate for Methionine in order to prevent oxidation of Met.
Scaleable catalytic asymmetric Strecker syntheses of unnatural alpha-amino acid; S. J. Zuend, M. P. Coughlin, M. P. Lalonde, E. N. Jacobsen; Nature 2009: 461(7266): 968-70. https://doi.org/10.1038/nature08484.
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