Chemical name: N-alpha-t-Butyloxycarbonyl-O-(2-azidoethyl)-L-tyrosine // Synonyms: Boc-O-(2-azidoethyl)-L-tyrosine, Boc-4-(2-azidoethoxy)-L-phenylalanine, Boc-Tyr(Azidoethyl)-OH, Boc-L-Tyr(Azidoethyl)-OH,(S)-3-(4-(2-azidoethoxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid, Boc-O-(2-azidoethyl)-L-Tyr-OH, Boc-Tyr(2-azidoeth

  • Product code:BAA4650
  • CAS No.:1434445-10-9
  • Formula:C16H22N4O5
  • Molecular weight:350.38 g/mol

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This unnatural Boc-protected Tyrosine derivative bears an azidoethyl substitution as reactive handle e.g. for biorthogonal conjugations, via a Cu(I)-catalyzed 1,3-dipolar Click cycloaddition with alkynes. Furthermore, azido-UAAs can be employed as IR reporters.


Structure-Based Design of Inhibitors Selective for Human Proteasome b2c or b2i Subunits; B.-T. Xin, E. M. Huber, G. de Bruin, W. Heinemeyer, E. Maurits, C. Espinal, Y. Du, M. Janssens, E. S. Weyburne, A. F. Kisselev, B. I. Florea, C. Driessen, G. A. van der Marel, M. Groll, H. S. Overkleeft; J. Med. Chem. 2019; 62(3): 1626-1642.

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