Amino Acids

  1. Glycosylated Asparagine Building Blocks for SPPS

    Add glycans to your proteins with our ready-to-use Fmoc asparagine building blocks suitable for solid phase peptide synthesis and produce peptides with exactly defined glycosylation patterns!

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  2. Automated Peptide Synthesis

    The discovery of the Merrifield peptide synthesis paved the way for automated solid-phase peptide synthesis (SPPS) enabling fast and convenient simultaneous peptide synthesis.

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  3. PotM: Small-sized, neutral fluorogenic amino acids suitable for SPPS

    Discover our small-sized, neutral Fmoc-protected nitrobenzoselenadiazole- and nitrobenzothiadiazole-modified amino acids suitable for SPPS of fluorescent peptides. 

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  4. PotM: Next Generation Lysine Side Chain Protecting Groups

    Sick of Lysine side chain protecting groups jumping around, yielding scrambled peptides? Check our various options to fine-tune protecting group stability vs. cleavability to optimize your peptide yield.

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  5. Process Development – From Discovery to Scale-up

    Ongoing research efforts lead to the discovery of innovative building blocks and new APIs. However, for industrial applications, upscaling is required. Herein, we share the process development for Fmoc-Cys(Msbh)-OH.

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  6. Cyanobenzothiazole (CBT) Derivatives for “Click” Conjugation

    Discover the cyanobenzothiazole (CBT) click reaction, a not (yet) so well-known biocompatible and bio-orthogonal mechanism faster than the famous azide-alkyne cycloaddition (CuAAC).

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  7. PotM: Safety Catch - Orthogonally Protected Amino Acids

    Add a new dimension of orthogonality to your peptide synthesis by using Safety-Catch arylalkyl sulfoxide protecting groups! This newsletter tells you about benefits and usage – Read on!

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  8. Photoaffinity Labeling by Diazirine Building Blocks

    Discover our diazirine-substituted building blocks suitable for the analysis of protein-protein and RNA-protein interactions via proximity labeling upon photoactivation. Read on for more information!

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  9. Carbamidomethylated Cysteine as SPPS Building Block

    Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and carbamido-methylated protein fragments by standard SPPS without error-prone modification reactions.

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  10. Fatty Di-Acids

    Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!

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