Click Chemistry Tools: Propargyl Amino Acids

Published on 03/12/2015

Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions. We offer a variety of different propargyl amino acids for both Fmoc and Boc strategies, for enzymatic synthesis, as well as preloaded resins for SPPS.

Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions without having to resort to complicated protecting group chemistry. Clickable groups include various tags and labels, as well as other biomolecules, such as carbohydrates. Furthermore, click chemistry facilitates otherwise challenging reactions such as peptide macrocyclization.

Click Chemistry Tools: Propargyl Amino Acids

We offer an extensive selection of different propargyl amino acids for both Fmoc and Boc strategies, as well as unprotected propargyl amino acids for enzymatic peptide synthesis. Moreover, for your convenience, Iris supplies resins preloaded with propargyl amino acids.

→ Find azido-functionalized clickable PEGs, Poly-amino-acids and Dendrimers/Dendrons in our Drug Delivery section
→ Find azido-functionalized clickable Carbohydrates, Dyes, Labels and more in our Life Sciences section
→ Do you want to know more about Click Chemistry? Order our special catalogue “Everything for Click Chemistry” free of charge.
→ Can’t find the amino acid you need?
→ Need a linker for Cu-free Click Conjugation?

Inquire with our Custom Synthesis Service!

Specific and quantitative labeling of biomolecules using click chemistry; K. Horisawa; Frontiers in physiology 2014; 5: 457. doi:10.3389/fphys.2014.00457
Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide–alkyne “click” chemistry; J.-F. Lutz and Z. Zarafshani; Advanced Drug Delivery Reviews 2008; 60: 958-970. doi:http://dx.doi.org/10.1016/j.addr.2008.02.004 Click Chemistry as a Macrocyclization Tool in the Solid-Phase Synthesis of Small Cyclic Peptides; R. A. Turner, A. G. Oliver and R. S. Lokey; Organic Letters 2007; 9: 5011-5014. doi:10.1021/ol702228u
Reprogramming Nonribosomal Peptide Synthetases for “Clickable” Amino Acids; H. Kries, R. Wachtel, A. Pabst, B. Wanner, D. Niquille and D. Hilvert; Angewandte Chemie International Edition 2014; 53: 10105-10108. doi:10.1002/anie.201405281
Pyrrolysine Encoded by UAG in Archaea: Charging of a UAG-Decoding Specialized tRNA; G. Srinivasan, C. M. James and J. A. Krzycki; Science 2002; 296: 1459-1462. doi:10.1126/science.1069588
Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair; S. M. Hancock, R. Uprety, A. Deiters and J. W. Chin; Journal of the American Chemical Society 2010; 132: 14819-14824. doi:10.1021/ja104609m