Drug Delivery

  1. Pharmacological Effects of Polymer Therapeutics

    Small drug molecules and also large biomolecules like proteins or antibodies suffer rapid clearance from human body.

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  2. PEG-Conjugates of Folic Acid and Cholesterol

    Conjugates of PEG and folic acid or cholesterol, respectively, combine the positive properties of these molecules. Those conjugates are available with a wide variety of functional groups and different PEG chain lengths to suit your needs.

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  3. Amino Aldehydes

    Aldehydes are between alcohols and carboxylic acids with respect to their oxidation level and show specific reactivity. Therefore they are highly interesting building blocks and intermediates for a large number of very interesting classes of reactions and compounds such as Wittig reaction, formation of secondary alcohols, heterocycles and semiaminals to name only a few.

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  4. Amino-PEG-Acids for Increased Solubilization.

    For introducing amino-PEG-acids into a peptide chain, several affordable building blocks are available with all conventional protecting groups. They can be incorporated at any sequence position by standard coupling protocols.

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  5. New: dPEG-Phospholipids for superior liposomes

    Novel liposomes built of dPEG-Phospholipids with defined PEG chain length provide prolonged blood-circulation time and improved cellular uptake as administration carriers for drugs, delivering active molecules to the desired target.

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  6. Versatility of N3-AEEA, a short, monodiosperse Azido-PEG-carboxylic acid

    The azido function can be used for different applications

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  7. Cross-Linker: Mal-AMCHC-OSu

    Mal-AMCHC-OSu

    trans-N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate

    Formula:                    C16H18N2O6
    Molecular Weight:     334,33 g/mole

    CAS:  64987-85-5

    CODE:  MAA1000

    1g:       EUR    300,-    US$   420,-
    5g:       EUR  1200,-    US$ 1680,-

    Prices are in EUR, net, exw Germany, shipping not include

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  8. Dendron Building Blocks for Click Chemistry

    Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block.

    The size can be designed from 250 g/mole for 1st generation dendrons to over 4400 g/mole with 5th generation compounds. Dendrimers can be designed reaching even a molecular weight of some 10.000 Da. As focal point alkyne and azido functions are used with appropriate counter parts in any type of click chemistry reaction. Olefinic functions offer the possibility for addition reaction or conjugation by metathesis reactions or photo reactions with the aid of UV light. For the modification of Gold surfaces sulphur bearing dendrons can be used, they also conjugate with biologicals via disulfide bridge formation.

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  9. PEGylation - The Magic Wand IRIS Biotech GmbH - Turning Proteins and other Biopharmaceuticals into Super Performing Block Busters

    Abstract: In 2006 the market of modern biopharmaceuticals has reached a volume of over 3 billion in USA and over billion world wide (IMS Health, Inc.).

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