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Published on 14/09/2017
However, in case of difficult or sensitive sequences, there are alternative deprotection reagents that can be employed, such as the non-nucleophilic base DBU in DMF. Another useful alternative to piperidine is 4-methylpiperidine, which has been shown to deprotect the Fmoc group as efficiently as piperidine (Hachmann and Lebl, J. Comb. Chem. 2006).
An additional benefit of both DBU and 4-methylpiperidine is that in contrast to piperidine, these compounds are no controlled substances and do not require an end-user declaration. While piperidine requires a lot of paperwork and is subject to various export limitations, this is not the case for DBU and 4-methylpiperidine.
In our webshop you can find all these tried and tested reagents for Fmoc removal. The latest addition to this range is a premixed solution of 20% piperidine in DMF that can be conveniently used straight out of the bottle.
Removal of the relatively acidic proton on C9 of the fluorenyl moiety by piperidine.
→ Be prepared for the step following Fmoc deprotection: check out our large selection of Coupling Reagents.