Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying though a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.Continue to Iris Biotech GmbHSend request to US distributor
Published on 19/12/2022
Abstract: Solid-Phase Peptide Synthesis (SPPS) is a convenient and efficient method by which to prepare peptides. However, the sequences of compounds classified as “difficult” show aggregation of growing peptide chains and their synthesis is extremely challenging by stepwise SPPS. In this context, the concourse of pseudoproline derivatives helps to break the aggregation and facilitates the synthesis. Although pseudoproline moieties are traditionally incorporated as dipeptides, the possibility of using only the monomer adds flexibility to the synthesis. Herein, the introduction of the most hindered β-branched Thr[ψMe,Mepro] derivative is studied in terms of how difficult is its acylation is by the following amino acid and the impact of its use on the final purity of two well-known ”difficult peptides”.