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Life Sciences
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Betulins – Potent Natural Products
Betulin and its derivatives are pentacyclic triterpenoids of the lupane-type. They are natural products that occur as secondary metabolites in over 200 different plants. Betulinic acid (BA) is a derivative of betulin that is oxidized at C-28.
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Product of the Month: Biotin-Aniline for Proximity Labeling of RNA
Proximity labeling of proteins with biotin-phenol (biotin-tyramide) and an engineered peroxidase enzyme (e.g. APEX = Engineered Ascorbate Peroxidase) is a pivotal tool for molecular biology.
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Protease Inhibitors
Protease inhibitors are molecules that inhibit protease function by binding either reversibly or irreversibly to the enzyme.
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Membrane-Impermeant Biotin Tyramide
Methods for proteomic mapping of cellular organelles or subdomains that avoid the necessity of cell lysis and purification by targeting specific subcellular regions have several advantages.
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Amadori & Maillard reaction derived peptides
Find below derivatives of arginine and lysine bearing side chains as found in Maillard reaction products.
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(TPP-Lys(TPP))2-Lys-Gly-Gly-Gly-N2H3*4Br*TFA
Delivery of hydrophilic compounds across membranes is usually problematic. Modification with triphenylphosphonium ions has been shown to overcome this barrier.
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Product of the Month: Indocyanine Green (ICG) Dyes
Indocyanine Green (ICG) dye, a material approved by the FDA for various applications, is a powerful tool for imaging in live cells and tissues.
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A Cyclo-RGD Peptide for the Preparation of Tumor Mimics
The 2D monolayer cell culture model is widely applied for drug screening. However, this approach is frequently not able to adequately mimic the in vivo response.
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Lysine Dendrons
We now offer a series of Lysine dendrons for chemoselective functionalization of molecules containing carbonyl groups. These multivalent molecules carry diverse types of moieties, such as amine- or hydroxyl-groups, DOTA chelators or triphenylphosphonium (TPP) cations.
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