Product Focus

  1. Omniligase-1 for Efficient Peptide Ligation

    Omniligase-1 enables efficient and racemization-free ligation of two side-chain unprotected peptide fragments at many different positions. Test this innovative enzyme developed by EnzyPep B.V. using the complementary model peptides included in our kit!

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  2. The Safety-Catch Acid-Labile (SCAL)-Linker

    The SCAL linker offers superior chemical stability and permits a variety of orthogonal solid-phase approaches. It is fully compatible with the Fmoc-, Boc- and Alloc- strategies. Cleavage can be performed either by a simultaneous, or by a two-step reduction/acidolysis procedure to afford peptide amides.

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  3. New Iris Kits for the Synthesis of Peptoids and N-Alkylated Peptides

    Peptides as pharmaceutical compounds suffer from unfavorable pharmacokinetics which is, among other things, due to a slow uptake into cells and rapid proteolytic cleavage. N-Alkylation of peptides is a valuable tool to overcome these limitations. We now offer new kits that enable the facile preparation of peptoids and N-alkylated peptides.

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  4. Chlorotoxin & Biotin-Chlorotoxin

    Chlorotoxin is a chloride channel blocker which has been found in the venom of the Egyptian scorpionLeiurus quinquestriatus.

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  5. Fast and Easy Protease Kinetics with Asymmetric Rhodamine 110 Substrates

    Asymmetric Rhodamine 110 protease substrates are used for the determination of protease kinetics. The asymmetric structure of these dyes greatly simplifies the determination of enzyme kinetics, while the properties of Rhodamine 110 facilitate an uncomplicated readout.

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  6. THPTA: Ligand-accelerated Click Chemistry in Aqueous Solution

    Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.

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  7. Furyl-Alanine: A Novel Photo-Click Amino Acid

    2-Furyl-alanine can be incorporated into peptides via SPPS or by using enzymatic approaches. UV-irradiation in the presence of oxygen and a photosensitizer converts furyl-alanine to an intermediate that selectively reacts with certain nucleophiles. This property can be employed for site-specific labeling of peptides and proteins.

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  8. Targeted and Reversible Biotinylation with Biotin-SS-Tyramide

    Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted targeted protein biotinylation. By using peroxidase-tagged antibodies, proteins and protein clusters can be selectively biotinylated, and then isolated using streptavidin. The biotin tag can be subsequently removed using reducing agents (e.g. glutathione).

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  9. Fmoc-Phe-Aca: Fluorescent Internalization Reporter for Cell Penetrating Peptides (CPPs)

    The Fmoc-L-Phe-Aca pseudo-dipeptide is a useful reporter group for the successful internalization of CPPs. Phe quenches the fluorescence of Aca. Internalization of the peptide containing Phe-Aca leads to proteolytic cleavage of the Phe-Aca bond and thus to fluorescence.

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  10. Siderophore Building Block: New Hydroxamate-Ornithine for Fmoc/tBu SPPS

    Nδ-hydroxy-Nδ-acetyl-ornithine, an important constituent of many siderophores, is now available for your convenience as Nα-Fmoc-Nδ-(acetyl)-Nδ-(benzoyloxy)-ornithine building block which can be used in standard Fmoc/tBu SPPS and permits facile on-resin Nδ-deprotection.

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