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Published on 11/01/2022
In the field of amino acid derivatives, we introduced among others two innovative protecting groups: on the one hand, we presented a cyanosulfurylide as carboxylic acid protecting group for Aspartate (FAA8480) preventing aspartimide formation during peptide synthesis. On the other hand, we highlighted SIT (sec-isoamyl mercaptan), a disulfide-based Cysteine protecting group (FAA8495) fully compatible with Fmoc- and Boc-SPPS, which is superior to StBu and SDMP, and can easily be removed reductively upon addition of dithiothreitol.
Interested in additional Cysteine protecting groups? See our Cyclic Peptides Brochure.
Speaking of Cysteines, we also presented various Selenocysteines (Sec) as versatile building blocks for native chemical ligation (NCL) and as biologically relevant element (see related products). Working on NCL? Download our booklet.
Regarding our Linkerology® portfolio, we would like to highlight especially two product classes:
Disulfide-based self-immolative linkers for specific intracellular drug release upon glutathione reduction allowing spatial and temporal control of payload release. As the overall redox potential in the human blood is oxidative, disulfide linkages are stable during circulation. In contrast, the intracellular milieu is characterized by an overall reductive potential. Furthermore, cytoplasm typically shows millimolar (1-10 mM) concentrations of the reductant tripeptide glutathione (GSH) in contrast to 2-10 µM in blood.
Besides, amino acid loaded methoxyphenoxypropanoic acid (MPPA) building blocks are highlighted as alternatives to Wang resin, avoiding racemization of the C-terminal amino acid during SPPS and enabling the synthesis of very pure peptides.
For further information, feel free to check-out or brochure.
Concerning the field of life sciences, we highlighted Haloalkane Dehalogenase substrates bearing different terminal functional groups suitable for further conjugation. The HaloTag® represents a versatile protein labeling system. Besides, Iris Biotech is also offering substrates for the so-called SNAP-tag, another type of polypeptide protein tag.
One of our latest product innovations within the category building blocks are pseudoproline monomers. Typically known and employed as preformed building dipeptides, we presented Fmoc-protected Serine- (FAA8590) and Threonine- (FAA8695) derived pseudoproline monomers as building blocks for solid-phase peptide synthesis preventing aggregation and increasing overall efficiency. Those two building blocks avoid the requirement for pseudoproline dipeptides, which are commercially available only in limited combinations, giving the possibility to introduce pseudoprolines in peptides containing non-natural or rare amino acids.