Ramage Resin

Chemical name: Fmoc-Ramage-Amide-(aminomethyl)-Resin // Synonyms: DCHD Resin, Ramage Amide AM Resin, 2-(5-(9-Fluorenylmethyloxycarbonyl)amino-10,11-dihydro-5H-dibenzo[a,d]cycloheptenyl-2-oxy)actamido polystyrene

  • Product code:BR-2015
  • Particle size :200-400 mesh
  • DVB crosslinking :1% DVB
  • Loading:0.4-0.8 mmol/g

Starting at $258.75

Grouped product items
Qty Packing unit Price SKU
5 g
$258.75
BR-2015.0005
25 g
$862.50
BR-2015.0025
100 g
$3,047.50
BR-2015.0100
Safety Data Sheets
description

Alternative to the commonly used Rink-resin. The three-circular structure of the Ramage linker prevents fragmentation of the linker during cleavage from the resin followed by back alkylation. A common phenomenon observed during peptide synthesis with the open structure of the Rink-amide linker. Hence, Ramage linker delivers peptides with higher purity and less impurities, than peptides produced with the Rink-amide linker. Ramage resin is particularly recommended for C-terminal Phe, Tyr and Ile. Following Fmoc removal, the resin can be acylated under standard conditions with Fmoc/tBu protocols. Peptide amides can be released from the resin with 50% TFA in DCM or 95% aqueous TFA.


references

Potassium channel modulation by a toxin domain in matrix metalloprotease 23; S. Rangaraju, K. K. Khoo, Z. P. Feng, G. Crossley, D. Nugent, I. Khaytin, V. Chi, C. Pham, P. Calabresi, M. W. Pennington, R. S. Norton and K. G. Chandy; J Biol Chem 2010; 285: 9124-36. https://doi.org/10.1074/jbc.M109.071266

An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii; R. V. Baudinette, P. Boontheung, I. F. Musgrave, P. A. Wabnitz, V. M. Maselli, J. Skinner, P. F. Alewood, C. S. Brinkworth and J. H. Bowie; FEBS J 2005; 272: 433-43. https://doi.org/10.1111/j.1742-4658.2004.04483.x

Evaluation of some fluorogenic substrates for continuous assay of aminopeptidase P; S. J. Hawthorne, P. Harriott, J. Lim, A. J. Turner, B. Walker and C. H. Williams; Anal Biochem 1997; 253: 13-7. https://doi.org/10.1006/abio.1997.2320

Design of a versatile linker for solid phase peptide synthesis: Synthesis of C-terminal primary/seconary amides and hydrazides; R. Ramage, S. L. Irving and C. McInnes; Tetrahedron Letters 1993; 34: 6599-6602. https://doi.org/10.1016/0040-4039(93)88115-y


Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information of this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!