Ramage Resin

Chemical name: 2-(5-(9-Fluorenylmethyloxycarbonyl)amino-10,11-dihydro-5H-dibenzo[a,d]cycloheptenyl-2-oxy)actamido polystyrene // Synonyms: DCHD Resin, Ramage Amide AM Resin

Product code:BR-5204
Particle size :100-200 mesh
DVB crosslinking :1% DVB
Loading:0.5-1.3 mmol/g
Grouped product items
Qty Packing unit Price SKU
1 g
$202.50
BR-5204.0001
5 g
$810.00
BR-5204.0005
Safety Data Sheets
description
Alternative to the commonly used Rink-amide linker. The three-circular structure of the Ramage linker prevents fragmentation of the linker during cleavage from the resin followed by back alkylation. A common phenomenon observed during peptide synthesis with the open structure of the Rink-amide linker. Hence, Ramage linker delivers peptides with higher purity and less impurities, than peptides produced with the Rink-amide linker. Following Fmoc removal, the resin can be acylated under standard conditions and used in SPPS with Fmoc/tBu protocols. Peptide amides can be released from the resin with 3% TFA in DCM. Thus it is a useful tool for the synthesis of acid sensitive peptides or protected peptide fragments.

references
Design of a versatile linker for so lid phase peptide synthesis: Synthesis of C-terminal primary/seconary amides and hydrazides. R. Ramage, S.L. Irving, C. McInnes; Tetrahedron Lett. 1993; 34: 6599-6602. DOI: 10.1016/0040-4039(93)88115-Y

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