Fmoc-L-Hse(Trt)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-trityl-L-homoserine // Synonyms: Fmoc-Hse(Trt)-OH

  • Product code:FAA1105
  • CAS No.:111061-55-3
  • Formula:C38H33NO5
  • Molecular weight:583,7 g/mol

Starting at $175.00

Grouped product items
Qty Packing unit Price SKU
5 g
$175.00
FAA1105.0005
25 g
$700.00
FAA1105.0025
Safety Data Sheets
description

The Trt group can be removed with 1% TFA in dichloromethane (silanes as scavengers) while tBu-type protecting groups stay intact. Resin bound Hse(Trt), Ser(Trt), Thr(Trt), and Tyr(Clt) are versatile building blocks for on-resin side chain modifications, like phosphorylation, sulfonation or PEGylation.


references

1. Preparation and application of N-Fmoc-O-Trt-hydroxy amino acids for solid-phase synthesis of peptides; K.Barlos, D.Gatos, S.Koutsogianni, W.Schafer, G.Stavropoulos, Y.Wenqing; Tetrahedron Lett. 1991; 32(4): 471-474.

2. Fmoc/Trt-amino acids: comparison to Fmoc/tBu-amino acids in peptide synthesis; K.Barlos, D.Gatos, S.Koutsogianni; J. Pept. Res. 1998; 51(3): 194-200.

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