Fmoc-beta,beta-diMe-L-Ser-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-beta,beta-dimethyl-L-serine // Synonyms: Fmoc-L-Hvl-OH, (S)-Fmoc-beta-hydroxy-valine, (S)-Fmoc-2-amino-3-hydroxy-3-methyl-butyric acid, (S)-Fmoc-beta,beta-dimethyl-serine,(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-hydroxy-3-methylbu tanoic acid

  • Product code:FAA2600
  • CAS No.:1217603-41-2
  • Formula:C20H21NO5
  • Molecular weight:355.38 g/mol

Starting at $130.00

Grouped product items
Qty Packing unit Price SKU
250 mg
$130.00
FAA2600.0250
1 g
$390.00
FAA2600.0001
5 g
$1,787.50
FAA2600.0005
25 g
$4,030.00
FAA2600.0025
description

beta,beta-Dimethylation of amino acids stabilizes appropriate peptides towards digestion by proteases. The hydroxyl function of this serine building block is unprotected, because acylation does not happen to tertiary alcohols during standard Fmoc/tBu coupling protocols.

references

A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates; Kathryn R. Heard, Wengen Wu, Youhua

Li, Peng Zhao, Iwona Woznica, Jack H. Lai, Martin Beinborn, David G. Sanford, Matthew T. Dimare, Amrita K. Chiluwal, Diane E. Peters, Danielle Whicher, James L. Sudmeier, and

William W. Bachovchin; J. Med. Chem. 2013; 56: 8339-8351. dx.doi.org/10.1021/jm400423p.

Total synthesis of the large non-ribosomal peptide polytheonamide B; Masayuki Inoue, Naoki Shinohara, Shintaro Tanabe, Tomoaki Takahashi, Ken Okura, Hiroaki Itoh, Yuki Mizoguchi,

Maiko Iida, Nayoung Lee and Shigeru Matsuoka; Nature Chem. 2010; 2: 281-285. DOI: 10.1038/nchem.554.

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!