Fmoc-Dbz-OH

Chemical name: 3-[(9-Fluorenylmethyloxycarbonyl)amino]-4-amino-benzoic acid // Synonyms: 3-Fmoc-4-diaminobenzoic acid

  • Product code:FAA3165
  • CAS No.:1071446-05-3
  • Formula:C22H18N2O4
  • Molecular weight:374,39 g/mol
  • Purity :> 97%

Starting at $144.90

Grouped product items
Qty Packing unit Price SKU
500 mg
$144.90
FAA3165.0500
1 g
$225.40
FAA3165.0001
5 g
$805.00
FAA3165.0005
25 g
$3,220.00
FAA3165.0025
Safety Data Sheets
description

Dbz is a novel linker for the synthesis of peptide thioesters by Fmoc SPPS . After Fmoc removal the resin is being acylated with the first amino acid and then peptide synthesis is carried out. Following chain assembly the resin is being activated by treatment with p-nitrophenyl chloroformate. TFA cleaves the fully deprotected peptide benzimidazolinone which can be converted to a thioester with aryl thiol or used directly in native chemical ligation.

references

A Reversible Protection Strategy To Improve Fmoc-SPPS of Peptide Thioesters by the N-Acylurea Approach; Santosh K. Mahto, Cecil J. Howard, John C. Shimko, and Jennifer J. Ottesen;

ChemBioChem 2011; 12: 2488-2494. DOI: 10.1002/cbic.201100472.

An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation; Blanco-Canosa, J. B. & Dawson, P. E.; Angew. Chem. Int. Ed.

2008; 47: 6851-6855.

Z. Harpaz, et al.; ChemBioChem 2010; 11: 1232.

B. L. Pentelute, et al., Chem. Biol. 2010; 5: 359.

T. K. Tiefenbrunn, et al.; Pept. Sci. 2010; 94: 405.

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information of this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!