Chemical name: 3-(Fmoc-amino)-4-(Alloc-amino)-benzoic acid // Synonyms: 4-Allyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-benzoic acid, 3-Fmoc-4-Alloc-diaminobenzoic acid, Fmoc-Dbz(o-Aloc)-OH

  • Product code:FAA3168
  • CAS No.:2143465-53-4
  • Formula:C26H22N2O6
  • Molecular weight:458.46 g/mol

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1 g
5 g
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Typically, 3,4-diaminobenzoid acid (Dbz) is used for the efficient synthesis of peptide thioesters by Fmoc chemistry solid phase peptide synthesis. Optionally, a solubility tag can be attached to the C-terminus. Orthogonal allyl-oxycarbonyl (Alloc) protection of the free amine prevents the formation of over-acylation side-products which are otherwise observed using the typical Dawson reagent.


A reversible protection strategy to improve Fmoc-SPPS of peptide thioesters by the N-Acylurea approach; S. K. Mahto, C. J. Howard, J. C. Shimko, J. J. Ottesen; Chembiochem 2011; 4: 2488-94.

Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags; S. Bondalapati, E. Eid, S. M. Mali, C. Wolberger, A. Brik; Chem. Sci. 2017; 8: 4027-4034.

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