Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying though a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.Continue to Iris Biotech GmbHSend request to US distributor
Chemical name: 4-(Difluorophosphonomethyl)-N-(9-fluorenylmethyloxycarbonyl)-L-phenylalanine // Synonyms: Fmoc-L-Phe(4-CF2PO3)-OH, Fmoc-L-p-(Phosphono-difluoromethyl)phenylalanine, (2S)-3-[4-[Difluoro(phosphono)methyl]phenyl]-2-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)propanoic acid, 4-(Difluorophosphonomethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-Phenylalanine
|Molecular weight:||517.42 g/mol|
Hydrolysis-stable mimic of Phosphotyrosine; fluorination makes the phoshonic acid more acidic and thus a better mimic of phosphotyrosine than Pmp (compare to FAA1745 Fmoc-L-Pmp-OH and FAA5590 Fmoc-L-Pmp(OtBu)2-OH)
An Intrinsic Hydrophobicity Scale for Amino Acids and Its Application to Fluorinated Compounds; W. Hoffmann, J. Langenhan, S. Huhmann, J. Moschner, R. Chang, M. Accorsi, J. Seo, J. Rademann, G. Meijer, B. Koksch, M. T. Bowers, G. von Helden and K. Pagel; Angew Chem Int Ed Engl 2019; 58: 8216-8220. https://doi.org/10.1002/anie.201813954
Phosphatase-Stable Phosphoamino Acid Mimetics That Enhance Binding Affinities with the Polo-Box Domain of Polo-like Kinase 1; D. Hymel and T. R. Burke, Jr.; ChemMedChem 2017; 12: 202-206. https://doi.org/10.1002/cmdc.201600574
Cell-permeable bicyclic peptidyl inhibitors against T-cell protein tyrosine phosphatase from a combinatorial library; H. Liao and D. Pei; Org Biomol Chem 2017; 15: 9595-9598. https://doi.org/10.1039/c7ob02562a
Azide-alkyne cycloaddition-mediated cyclization of phosphonopeptides and their evaluation as PTP1B binders and enrichment tools; C. Meyer, B. Hoeger, J. Chatterjee and M. Kohn; Bioorg Med Chem 2015; 23: 2848-53. https://doi.org/10.1016/j.bmc.2015.03.015
Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells; C. Meyer, B. Hoeger, K. Temmerman, M. Tatarek-Nossol, V. Pogenberg, J. Bernhagen, M. Wilmanns, A. Kapurniotu and M. Kohn; ACS Chem Biol 2014; 9: 769-76. https://doi.org/10.1021/cb400903u
A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes; S. Zhang, S. Liu, R. Tao, D. Wei, L. Chen, W. Shen, Z. H. Yu, L. Wang, D. R. Jones, X. C. Dong and Z. Y. Zhang; J Am Chem Soc 2012; 134: 18116-24. https://doi.org/10.1021/ja308212y
Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy; S. Zhang, L. Chen, Y. Luo, A. Gunawan, D. S. Lawrence and Z. Y. Zhang; J Am Chem Soc 2009; 131: 13072-9. https://doi.org/10.1021/ja903733z
Cellular effects of small molecule PTP1B inhibitors on insulin signaling; L. Xie, S. Y. Lee, J. N. Andersen, S. Waters, K. Shen, X. L. Guo, N. P. Moller, J. M. Olefsky, D. S. Lawrence and Z. Y. Zhang; Biochemistry 2003; 42: 12792-804. https://doi.org/10.1021/bi035238p
Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure; K. Shen, Y. F. Keng, L. Wu, X. L. Guo, D. S. Lawrence and Z. Y. Zhang; J Biol Chem 2001; 276: 47311-9. https://doi.org/10.1074/jbc.M106568200
Why is phosphonodifluoromethyl phenylalanine a more potent inhibitory moiety than phosphonomethyl phenylalanine toward protein-tyrosine phosphatases?; L. Chen, L. Wu, A. Otaka, M. S. Smyth, P. P. Roller, T. R. Burke, Jr., J. den Hertog and Z. Y. Zhang; Biochemical and biophysical research communications 1995; 216: 976-84. https://doi.org/10.1006/bbrc.1995.2716
Potent inhibition of insulin receptor dephosphorylation by a hexamer peptide containing the phosphotyrosyl mimetic F2Pmp; T. R. Burke, Jr., H. K. Kole and P. P. Roller; Biochemical and biophysical research communications 1994; 204: 129-34. https://doi.org/10.1006/bbrc.1994.2435
Do you need larger quantities for your development or production?
Please send me more information about