Fmoc-L-Cys(Allocam)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-((allyloxycarbonylamino)methy)-L-cysteine // Synonyms: Fmoc-Cys(Allocam)-OH, (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-((allyloxycarbonylamino)methylthio)propanoic acid

  • Product code:FAA7610
  • CAS No.:232953-09-2
  • Formula:C23H24N2O6S
  • Molecular weight:456.51 g/mol

Starting at $247.00

Grouped product items
Qty Packing unit Price SKU
250 mg
$247.00
FAA7610.0250
1 g
$715.00
FAA7610.1000
5 g
$2,860.00
FAA7610.5000
description

A novel strategy for the on-resin construction of disulfides via Allocam-protected cysteines. This palladium-mediated approach is mild and yields in pure disulfide bridged peptides with no observation of reduced peptide intermediates or S-allylated products.

references

Direct Palladium-Mediated On-Resin Disulfide Formation from Allocam Protected Peptides; Thilini D. Kondasinghe, Hasina Y. Saraha, Samantha B. Odeesho, and Jennifer L. Stockdill; Org Biomol Chem. 2017; 15(14): 2914–2918. DOI:10.1039/c7ob00536a.

Allylic protection of thiols and cysteine: I: The allyloxycarbonylaminomethyl group; André Malanda Kimbonguila, Ahmed Merzouk, François Guibé, Albert Loffet; Tetrahedron 1999; 55(22): 6931-6944. DOI: org/10.1016/S0040-4020(99)00322-1.

AM Kimbonguila, A Merzouk, F Guibé, A Loffet.; Tetrahedron Lett 1994; 35: 9035– 9038.


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