Fmoc-L-Phe(4-CH2-N3)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-4-azidomethyl-L-phenylalanine // Synonyms: Fmoc-Phe(4-CH2-N3), Fmoc-p-azidomethyl-L-phenylalanine, Fmoc-para-methylazido-L-phenylalanine, Fmoc-para-azidomethyl-L-phenylalanine, Fmoc-pN3CH2Phe, Fmoc-pAMF, Fmoc-4-(azidomethyl)-L-phenylalanine

Art-No.:FAA7740
Cas-no.:2375587-79-2
Formula:C25H22N4O4
Molecular weight:442,47 g/mol
Grouped product items
Product variant
250 mg
$162.00
FAA7740.0250
500 mg
$297.00
FAA7740.0500
1 g
$405.00
FAA7740.0001
5 g
$1,620.00
FAA7740.0005
description
This material is used in antibody drug conjugates as a superior SPAAC reaction partner in comparison to H-Phe(4-N3). It can serve as a vibrational reporter of local protein environments after genetic incorporation into proteins.

references
P roduction of Site-Specific AntibodyDrug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System; Erik S. Zimmerman, Tyler H. Heibeck, Avinash Gill, Xiaofan Li, Christopher J. Murray, Mary Rose Madlansacay, Cuong Tran, Nathan T. Uter, Gang Yin, Patrick J. Rivers, Alice Y. Yam, Willie D. Wang, Alexander R. Steiner, Sunil U. Bajad, Kalyani Penta, Wenjin Yang, Trevor J. Hallam, Christopher D. Thanos, Aaron K. Sato; Bioconjugate Chem. 2014; 25(2): 351-361. DOI:10.1021/bc400490z.

Sensitive, Site-Specific, and Stable Vibrational Probe of Local Protein Environments: 4-Azidomethyl-l-Phenylalanine; Christopher G. Bazewicz, Melanie T. Liskov, Kevin J. Hines, Scott H. Brewer;

J. Phys. Chem. B 2013; 117(30): 8987-8993. DOI:10.1021/jp4052598;

Methods of using anti-cd74 antibodies and antibody conjugates in treatment of t-cell lymphoma; Molina, Arturo; PCT Int. Appl. 2019; WO 2019023316 A1.

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