Fmoc-L-Asp-OMpe

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid alpha-3-methylpentyl ester // Synonyms: Fmoc-Asp-OMpe, N-alpha-Fmoc-aspartic acid alpha 3-methyl-pent-3-yl ester, (S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-((3-methylpentan-3-yl)oxy)-4-oxobutanoic acid,Fmoc-Asp-OMpe

  • Product code:FAA8090
  • CAS No.:2576508-17-1
  • Formula:C25H29NO6
  • Molecular weight:439.51 g/mol

Starting at $390.00

Grouped product items
Qty Packing unit Price SKU
1 g
$390.00
FAA8090.0001
5 g
$1,560.00
FAA8090.0005
description

An excellent derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides. The bulky OMpe protecting group provides considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu group.


references

A new protecting group for aspartic acid that minimizes piperidine-catalyzed aspartimide formation in Fmoc solid phase peptide synthesis. Amelie Karlström, Anders Undén; Tetrahedron Lett. 1996; 37(24): 4243-4246. DOI: 10.1016/0040-4039(96)00807-6

The aspartimide problem in Fmoc‐based SPPS. Part II. M. Mergler, F. Dick, B. Sax, C. Stähelin, T. Vorherr; J. Pept. Sci. 2003; 9(8): 518-526. DOI: 10.1002/psc.473

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