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Fmoc-L-Asp(OBno)-OH
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid beta-(5-butylnon-5-yl) ester // Synonyms: Fmoc-Asp(OBno)-OH, N-alpha-Fmoc-(O-5-(n-butyl)-non-5-yl)aspartic acid, (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-((5-butylnonan-5-yl)oxy)-4-oxobutanoic acid,Fmoc-Asp(OBno)-OH
- Product code:FAA8125
- CAS No.:1799418-06-6
- Formula:C32H43NO6
- Molecular weight:537.70 g/mol
Starting at $227.50
description
An extremely effective derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides. The bulky OBno protecting group provides considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu and OMpe groups.
references
Preventing aspartimide formation in Fmoc SPPS of Asp-Gly containing peptides - practical aspects of new trialkylcarbinol based protecting groups. Raymond Behrendt, Simon Huber, Peter White; J. Pept. Sci. 2016; 22(2):, 92-97. DOI:10.1002/psc.2844
New t-butyl based aspartate protecting groups preventing aspartimide formation in Fmoc SPPS. Raymond Behrendt, Simon Huber, Roger Marti, Peter White. J. Pept. Sci. 2015; 21(8):, 680-687. DOI:10.1002/psc.2790
Patent EP 2 886 531 B1
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