Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-5,5,5-trifluoro-L-norvaline // Synonyms: (S)-Fmoc-2-amino-5,5,5-trifluoropentanoic acid, Fmoc-L-5,5,5-trifluoronorvaline, (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5,5,5-trifluoropentanoic acid, Fmoc-TfNva-OH

  • Product code:FAA8315
  • CAS No.:144207-41-0
  • Formula:C20H18F3NO4
  • Molecular weight:393,36 g/mol
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Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable gamma-Secretase Inhibitor; K. W. Gillman, J. E. Starrett, Jr., M. F. Parker, K. Xie, J. J. Bronson, L. R. Marcin, K. E. McElhone, C. P. Bergstrom, R. A. Mate, R. Williams, J. E. Meredith, Jr., C. R. Burton, D. M. Barten, J. H. Toyn, S. B. Roberts, K. A. Lentz, J. G. Houston, R. Zaczek, C. F. Albright, C. P. Decicco, J. E. Macor and R. E. Olson; ACS Med Chem Lett 2010; 1: 120-4.

Enzymatic Preparation of an R-Amino Acid Intermediate for a γ-Secretase Inhibitor; R. L. Hanson, R. M. Johnston, S. L. Goldberg, W. L. Parker and A. Goswami; Organic Process Research & Development 2013; 17: 693-700.

Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution; H. Mei, J. Han, R. Takeda, T. Sakamoto, T. Miwa, Y. Minamitsuji, H. Moriwaki, H. Abe and V. A. Soloshonok; ACS Omega 2019; 4: 11844-11851.

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