Fmoc-L-Leu(F3)-OH

Chemical name: N-(9-Fluorenylmethyloxycarbonyl)-5,5,5-trifluoro-L-leucine // Synonyms: Fmoc-TfLeu-OH (2S,4RS), N-[(9H-fluoren-9-ylmethoxy)carbonyl]-5,5,5-trifluoro-L-leucine, (2S,4R)(2S,4S)-Fmoc-L-5,5,5-trifluroleucine,(2S,4R)(2S,4S)-Fmoc-2-amino-5,5,5-trifluoro-4-methylpentanoic acid

  • Product code:FAA8335
  • CAS No.:777946-04-0
  • Formula:C21H20F3NO4
  • Molecular weight:407,38 g/mol

Starting at Please inquire

Grouped product items
Qty Packing unit Price SKU
0 g Please inquire Please inquire FAA8335.0000
description

Partially fluorinated amino acid, which has been used to alter hydrophobicity, membrane affinity, and conformation of peptides.


references

Enzymatic N-terminal addition of noncanonical amino acids to peptides and proteins; R. E. Connor, K. Piatkov, A. Varshavsky and D. A. Tirrell; Chembiochem : a European journal of chemical biology 2008; 9: 366-9. https://doi.org/10.1002/cbic.200700605

Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine; Y. Tang, G. Ghirlanda, N. Vaidehi, J. Kua, D. T. Mainz, I. W. Goddard, W. F. DeGrado and D. A. Tirrell; Biochemistry 2001; 40: 2790-6. https://doi.org/10.1021/bi0022588

Self-association and membrane-binding behavior of melittins containing trifluoroleucine; A. Niemz and D. A. Tirrell; J Am Chem Soc 2001; 123: 7407-13. https://doi.org/10.1021/ja004351p

Amino acids and peptides. XXIII. Leu-enkephalin analogs containing a fluorinated amino acid at position 2, 4 or 5; M. Maeda, K. Kawasaki, T. Taguchi, Y. Kobayashi, Y. Yamamoto, K. Shimokawa, M. Takahashi, K. Nakao and H. Kaneto; Chem Pharm Bull (Tokyo) 1994; 42: 1658-62. https://doi.org/10.1248/cpb.42.1658

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!