Fmoc-Ddax-L-Ala-OH

Chemical name: N-alpha-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-6-((9-fluorenylmethyloxycarbonyl)amino)hexyl)-L-alanine // Synonyms: Fmoc-Ddax-Ala, Fmoc-Ddax-Ala-OH, (2S)-2-{[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexyl]amino}propanoic acid

  • Product code:FAA8435
  • CAS No.:2576507-90-7
  • Formula:C32H38N2O6
  • Molecular weight:546.65 g/mol
  • Purity :min. 99%
  • Enantiomeric Purity:min. 99,7%

Starting at $304.20

Grouped product items
Qty Packing unit Price SKU
500 mg
$304.20
FAA8435.0500
1 g
$473.20
FAA8435.1000
5 g
$1,690.00
FAA8435.5000
Safety Data Sheets
description

Used as an Alanine-containing next-generation traceless "helping hand" solubilizing tag in SPPS. This solves the low reactivity issue of the tag with a peptide. Several Lysine residues are attached to this linker using Fmoc-SPPS. The solubilising tag can be removed with 1M hydrazine or hydroxylamine solution.


references

Chemical synthesis of Shiga toxin subunit B using a next-generation traceless “helping hand” solubilizing tag; J. M. Fulcher, M. E. Petersen, R. J. Giesler, Z. S. Cruz, D. M. Eckert, J. N. Francis, E. M. Kawamoto, M. T. Jacobsen, and M. S. Kay; Org Biomol Chem. 2019; 17; 10237-10244. https://doi.org/10.1039/C9OB02012H


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