Fmoc-Hcan(Boc)-OH (S)

Chemical name: (S)-2-(Fmoc-amino)-5-(Boc-aminoxy)pentanoic acid // Synonyms: (S)-Fmoc-Hcan(Boc)-OH, Fmoc-L-Homocanaline(Boc)-OH, (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(((tert-butoxycarbonyl)amino)oxy)pentanoic acid, Fmoc-Hcan(Boc)-OH,Fmoc-(S)-Hcan(Boc)-OH, (N-a lpha-(9-Fluorenylmethyloxycarbonyl)-amino)-5-((t-b

  • Product code:FAA8445
  • CAS No.:204844-15-5
  • Formula:C25H30N2O7
  • Molecular weight:470.51 g/mol

Starting at $227.50

Grouped product items
Qty Packing unit Price SKU
100 mg
$227.50
FAA8445.0100
250 mg
$520.00
FAA8445.0250
1 g
$1,560.00
FAA8445.1000
Safety Data Sheets
description

L-homocanaline (HCan) represents a structural analogue of lysine, which contains a reactive alkyloxyamine side chain. The aminooxy group exhibits greater nucleophilicity than the corresponding primary amino group. It is therefore considered to react chemoselectively with carbonyl compounds by forming a kinetically stable oxime bond, which is more stable than an imine bond.


references

Chemoselectively adressable HCan building blocks in peptide synthesis: L-homocanaline derivatives; I. Lang, N. Donzé, P. Garrouste, P. Dumy, M. Mutter; J. Pept. Sci. 1998; 4: 72-80. https://doi.org/10.1002/(sici)1099-1387(199802)4:1<72::aid-psc130>3.0.co;2-g.


Receptor-templated stapling of intrinsically disordered peptide ligands; C. M. Haney, and W. S. Horne; Org. Biomol. Chem. 2015; 13: 4183-4189. https://doi.org/10.1039/C5OB00269A.


Synthetic derivatives of the SUMO consensus sequence provide a basis for improved substrate recognition; M. J. Leyva, Y. S. Kim, M. L. Peach, J. S. Schneekloth Jr.; Bioorg. Med. Chem. Lett. 2015; 25: 2146-2151. https://doi.org/10.1016/j.bmcl.2015.03.069.


Site-specific cross-linking of proteins to DNA via a new biorthogonal approach employing oxime ligation; S. S. Pujari, Y. Zhang, S. Ji, M. D. Distefano, and N. Y. Tretyakova; Chem. Commun. 2018; 54: 6296-6299. https://doi.org/10.1039/C8CC01300D.

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!