Fmoc-L-Tyr(SO3nP)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-(2,2-dimethylpropylsulfo)-L-tyrosine // Synonyms: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(((neopentyloxy)sulfonyl)oxy)phenyl)propanoic acid,O-[(2,2-dimethylpropoxy)sulfonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-Tyrosine, Fmoc-Tyr( SO3nP)-OH

  • Product code:FAA8490
  • CAS No.:878408-63-0
  • Formula:C29H31NO8S
  • Molecular weight:553.63 g/mol

Starting at $1,430.00

Grouped product items
Qty Packing unit Price SKU
5 g
$1,430.00
FAA8490.0005
Safety Data Sheets
description

A derivative for the synthesis of sulfotyrosine-containing peptides by Fmoc-SPPS. Tyrosine sulfation is a post translational modification that occurs on integral membrane and secreted proteins and plays a crucial role in mediating biological processes. Thus, this derivative is useful for the study of site-specific tyrosine sulfation and its effect on peptide stability and activity. The sulfate group of FAA8485 is protected with a neopentyl (nP) group, which is stable to TFA. Neopentyl groups can be removed by treatment with aqueous ammonium acetate (1-2 M, 37 °C water bath, 6-12 hrs) or sodiumazide (50 eq, 70 °C, 16 h).


references

Regulation of chemokine recognition by site-specific tyrosine sulfation of receptor peptides; L. S. Simpson, J. Z. Zhu, T. S. Widlanski, M. J. Stone; Chem. Biol. 2009; 16(2): 153-61. https://doi.org/10.1016/j.chembiol.2008.12.007.


Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). J. P. Ludeman, M. Nazari-Robati, B. L. Wilkinson, C. Huang, R. J. Payne, M. J. Stone; Org. Biomol. Chem. 2015; 13, 2162-2169. https://doi.org/10.1039/C4OB02262A.

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!