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Chemical name: 4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)tetrahydrothiopyran-4-carboxylic acid // Synonyms: Fmoc-4-amino-tetrahydrothiopyran-4-carboxylic acid, Fmoc-4-amino-THTP-4-COOH, Fmoc-4-amino-4-carboxytetrahydrothiopyran
A Fmoc-protected tetrahydrothiopyran substituted glycine suitable as mimic of Methionine and employed in the design of Met-containing peptide analogues with improved biological activity and enzymatic stability. Furthermore, this compound is reported for the synthesis of diethylglycine peptides via desulfurization.
Preparation of amino acid derivatives as probes for drug discovery; A. M. M. Mjalli, C. Wysong, J. Baudry, T. S. Yokum, R. Andrews, W. K. Banner; 2003; US 20030125315 A1.
Extended diethylglycine homopeptides formed by desulfurization of their tetrahydrothiopyran analogues; M. De Zotti, J. Clayden; Org. Lett. 2019; https://doi.org/10.1021/acs.orglett.9b00501.
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